The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes.
about
Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal modelMedical management of hereditary optic neuropathies.Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration.Vector platforms for gene therapy of inherited retinopathies.Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.Let There Be Light: Gene and Cell Therapy for Blindness.Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.The approaches for manipulating mitochondrial proteomeMitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations.Gene therapy for Leber congenital amaurosis: advances and future directions.Gene therapies for inherited retinal disorders.A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired FormsLeber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways.Leber Hereditary Optic Neuropathy: Exemplar of an mtDNA Disease.Gene therapy for inherited retinal and optic nerve degenerations.Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy.The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress.Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery.Genotype–phenotype correlations in mitochondrial optic neuropathies
P2860
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P2860
The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The optimized allotopic expres ...... ring mutations in these genes.
@en
type
label
The optimized allotopic expres ...... ring mutations in these genes.
@en
prefLabel
The optimized allotopic expres ...... ring mutations in these genes.
@en
P2093
P1476
The optimized allotopic expres ...... ring mutations in these genes.
@en
P2093
Aicha Bouaita
Marisol Corral-Debrinski
Paule Bénit
Pierre Rustin
Sami Ellouze
Sébastien Augustin
P304
P356
10.1016/J.BBAMCR.2008.04.018
P407
P577
2008-05-06T00:00:00Z