GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.
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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasisHeterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a HydraActivators of G protein signaling exhibit broad functionality and define a distinct core signaling triadSrc homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin.Expression of Girdin in primary hepatocellular carcinoma and its effect on cell proliferation and invasion.Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling.Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signalingCyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyFocal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins.Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin).Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer.Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/GirdinGα13 Stimulates the Tyrosine Phosphorylation of Ric-8A.Clinical implications of Girdin and PI3K protein expression in breast cancer.Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon CancerClinical significance of Girdin expression detected by immunohistochemistry in non-small cell lung cancer.Expression and clinical significance of girdin in gastric cancer.Emerging non-canonical functions for heterotrimeric G proteins in cellular signaling.The untapped potential of tyrosine-based G protein signaling.Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.Regulation, Signaling, and Physiological Functions of G-Proteins.GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron.Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer.Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.
P2860
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P2860
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.
description
2011 nî lūn-bûn
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2011年の論文
@ja
2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
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name
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.
@en
type
label
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.
@en
prefLabel
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.
@en
P2860
P356
P1476
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.
@en
P2093
Mikel Garcia-Marcos
Pradipta Ghosh
P2860
P304
P356
10.4161/CAM.5.3.15909
P577
2011-05-01T00:00:00Z