RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. - Wikidata - wikimedia - TriplyDB

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

http://www.wikidata.org/entity/Q39038213

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MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research Transcriptional regulation of chemokine genes: a link to pancreatic islet inflammation?Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway Clic4, a novel protein that sensitizes β-cells to apoptosis Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death Convergence and divergence of genetic and modular networks between diabetes and breast cancer.CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells.Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas.Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes.Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity.Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function.Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.Transcriptome Profiles Using Next-Generation Sequencing Reveal Liver Changes in the Early Stage of Diabetes in Tree Shrew (Tupaia belangeri chinensis)Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity.A Single-Cell Transcriptome Atlas of the Human Pancreas.The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes.PAR2 regulates regeneration, transdifferentiation, and death Viral infections in type 1 diabetes mellitus--why the β cells?Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.Role of the unfolded protein response in β cell compensation and failure during diabetes.A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.Islet inflammation in type 2 diabetes.The role of ER stress in lipid metabolism and lipotoxicity.C-peptide antioxidant adaptive pathways in β cells and diabetes.Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.Glucagon-like peptide 1 protects INS-1E mitochondria against palmitate-mediated beta-cell dysfunction: a proteomic study.Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells.A hypothetical model to solve the controversy over the involvement of UCP2 in palmitate-induced β-cell dysfunction.

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RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

http://www.wikidata.org/entity/Q39038213

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

RNA sequencing identifies dysr ...... aturated fatty acid palmitate.

@en

RNA sequencing identifies dysr ...... aturated fatty acid palmitate.

@nl

type

label

RNA sequencing identifies dysr ...... aturated fatty acid palmitate.

@en

RNA sequencing identifies dysr ...... aturated fatty acid palmitate.

@nl

prefLabel

RNA sequencing identifies dysr ...... aturated fatty acid palmitate.

@en

RNA sequencing identifies dysr ...... aturated fatty acid palmitate.

@nl

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RNA sequencing identifies dysr ...... aturated fatty acid palmitate.

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Daniel A Cunha

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Décio L Eizirik

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Guy Bottu

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Jean-Valery Turatsinze

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Laurence Ladriere

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Marco Bugliani

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Mariana Igoillo-Esteve

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Matilde Masini

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Olatz Villate

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1978-1993

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scholarly article

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10.2337/DB13-1383

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6

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63

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Piero Marchetti

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Baroj Abdulkarim

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2013-12-30T00:00:00Z

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24379348

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