Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome.
about
More than just skin deep: faciocutaneous clues to genetic syndromes with malignanciesRepeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disordersInitiation of genome instability and preneoplastic processes through loss of Fhit expressionSpontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.Induction of homologous recombination following in utero exposure to DNA-damaging agents.Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.Nucleotide metabolism, oncogene-induced senescence and cancer.Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphaseSAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.Causes and consequences of replication stress.Bloom syndrome with extensive pulmonary involvement in a childPyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication.Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative StressNucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans.Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.Fhit loss-associated initiation and progression of neoplasia in vitro.Replication fork dynamics and the DNA damage response.Homologous recombination as a replication fork escort: fork-protection and recovery.A Critical Balance: dNTPs and the Maintenance of Genome StabilityGenomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells.dNTP pools determine fork progression and origin usage under replication stress.A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survivalRev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells.Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
P2860
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P2860
Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Pyrimidine pool imbalance indu ...... instability in Bloom syndrome.
@en
Pyrimidine pool imbalance indu ...... instability in Bloom syndrome.
@nl
type
label
Pyrimidine pool imbalance indu ...... instability in Bloom syndrome.
@en
Pyrimidine pool imbalance indu ...... instability in Bloom syndrome.
@nl
prefLabel
Pyrimidine pool imbalance indu ...... instability in Bloom syndrome.
@en
Pyrimidine pool imbalance indu ...... instability in Bloom syndrome.
@nl
P2093
P2860
P356
P1476
Pyrimidine pool imbalance indu ...... instability in Bloom syndrome.
@en
P2093
Géraldine Buhagiar-Labarchède
Michelle Debatisse
Mounira Amor-Guéret
Olivier Brison
Pauline Chabosseau
Rosine Onclercq-Delic
Sarah Lambert
P2860
P2888
P356
10.1038/NCOMMS1363
P407
P577
2011-06-28T00:00:00Z
P6179
1019329707