Stat3 activation by Src induces specific gene regulation and is required for cell transformation.
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Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytesA gain-of-function mutation in STAT6The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motifMechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cellsErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cellsSH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiationDOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activationGRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interactionActivation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoproteinSignal transducers and activators of transcription as regulators of growth, apoptosis and breast development.Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cellsTyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer.Plant sterols as anticancer nutrients: evidence for their role in breast cancerEngaged for survival: From cadherin ligation to STAT3 activationHepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 ActivationActivation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular TransformationInositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicityMet receptor tyrosine kinase: enhanced signaling through adapter proteinsErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinasesThe hunting of the SrcConstitutive activation of STAT transcription factors in acute myelogenous leukemiaInterleukin-6, CD45 and the src-kinases in myeloma cell proliferationFunctional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1aTargeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solutionInterleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cellsSTAT3 as a therapeutic target in head and neck cancerInhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expressionSTAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motifBrevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cellsScoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activityPrevention of hypovolemic circulatory collapse by IL-6 activated Stat3Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformationExpression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.Cas mediates transcriptional activation of the serum response element by Src.Regulation of mRNA splicing and transport by the tyrosine kinase activity of src.The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells.STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor.
P2860
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P2860
Stat3 activation by Src induces specific gene regulation and is required for cell transformation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Stat3 activation by Src induce ...... uired for cell transformation.
@en
Stat3 activation by Src induce ...... uired for cell transformation.
@nl
type
label
Stat3 activation by Src induce ...... uired for cell transformation.
@en
Stat3 activation by Src induce ...... uired for cell transformation.
@nl
prefLabel
Stat3 activation by Src induce ...... uired for cell transformation.
@en
Stat3 activation by Src induce ...... uired for cell transformation.
@nl
P2093
P2860
P356
P1476
Stat3 activation by Src induce ...... uired for cell transformation.
@en
P2093
P2860
P304
P356
10.1128/MCB.18.5.2545
P407
P577
1998-05-01T00:00:00Z