Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). - Wikidata - wikimedia - TriplyDB

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

http://www.wikidata.org/entity/Q39668305

about

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase mTOR signaling in growth control and disease Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Crystal structures of the S6K1 kinase domain in complexes with inhibitors Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo Corticotropin releasing factor-induced CREB activation in striatal neurons occurs via a novel Gβγ signaling pathway Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.Phosphorylation of ribosomal protein S6 kinase 1 at Thr421/Ser424 and dephosphorylation at Thr389 regulates SP600125-induced polyploidization of megakaryocytic cell lines The p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer Growth The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids PI3K and cancer: lessons, challenges and opportunities Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity Advanced treatment for basal cell carcinomas.Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3 Epstein-Barr virus-encoded latent membrane protein 2A promotes the epithelial-mesenchymal transition in nasopharyngeal carcinoma via metastatic tumor antigen 1 and mechanistic target of rapamycin signaling induction.Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress.Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.Identification of fragile X syndrome specific molecular markers in human fibroblasts: a useful model to test the efficacy of therapeutic drugs.Development of organometallic S6K1 inhibitors.Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response.Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons.PF-4708671 activates AMPK independently of p70S6K1 inhibition.Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2 Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells.Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis.S6K1 controls pancreatic β cell size independently of intrauterine growth restriction S6Ks isoforms contribute to viability, migration, docetaxel resistance and tumor formation of prostate cancer cells.Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.eIF3 controls cell size independently of S6K1-activity.Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lung

P2860

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P2860

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

http://www.wikidata.org/entity/Q39668305

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Characterization of PF-4708671 ...... 70 ribosomal S6 kinase (S6K1).

@en

Characterization of PF-4708671 ...... 70 ribosomal S6 kinase (S6K1).

@nl

type

label

Characterization of PF-4708671 ...... 70 ribosomal S6 kinase (S6K1).

@en

Characterization of PF-4708671 ...... 70 ribosomal S6 kinase (S6K1).

@nl

prefLabel

Characterization of PF-4708671 ...... 70 ribosomal S6 kinase (S6K1).

@en

Characterization of PF-4708671 ...... 70 ribosomal S6 kinase (S6K1).

@nl

P1433

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P1433

Biochemical Journal

P1476

Characterization of PF-4708671 ...... 70 ribosomal S6 kinase (S6K1).

@en

P2093

Catherine Hwang

http://www.w3.org/2001/XMLSchema#string

Daniel T Richter

http://www.w3.org/2001/XMLSchema#string

Gordon R Alton

http://www.w3.org/2001/XMLSchema#string

John C Kath

http://www.w3.org/2001/XMLSchema#string

Justin Chapman

http://www.w3.org/2001/XMLSchema#string

Laura Lingardo

http://www.w3.org/2001/XMLSchema#string

P2860

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

P304

245-255

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scholarly article

P356

10.1042/BJ20101024

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P433

2

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P478

431

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P577

2010-10-01T00:00:00Z

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P698

20704563

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