Evolutionary and somatic selection of the antibody repertoire in the mouse.
about
Lack of allelic exclusion in B cell chronic lymphocytic leukemiaMechanism of somatic hypermutation at the WA motif by human DNA polymerase η.First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesMutation of POLB causes lupus in miceSevere attenuation of the B cell immune response in Msh2-deficient miceConstruction and characterization of single-chain variable fragment antibody library derived from germline rearranged immunoglobulin variable genesImmunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoireLongitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain.Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Antigenicity of fullerenes: antibodies specific for fullerenes and their characteristics.BASIC: BCR assembly from single cells.Stepwise intraclonal maturation of antibody affinity through somatic hypermutationSudden appearance of anti-protein IgG1-forming cell precursors early during primary immunizationHigh-resolution description of antibody heavy-chain repertoires in humans.Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakA natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation.AID and mismatch repair in antibody diversification.Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotypeAccumulation of VH Replacement Products in IgH Genes Derived from Autoimmune Diseases and Anti-Viral Responses in Human.Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cellsLocation and function of B-cell lineages.Repetitive usage of immunoglobulin VH and D gene segments in CD5+ Ly-1 B clones of (NZB x NZW)F1 miceDirected evolution using dCas9-targeted somatic hypermutation in mammalian cells.A structural basis for the biochemical behavior of activation-induced deoxycytidine deaminase class-switch recombination-defective hyper-IgM-2 mutantsTransgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.Antibodies that are specific for a single amino acid interchange in a protein epitope use structurally distinct variable regions.Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cellsComplete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient.Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutationClonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virusRearrangement and selection of VH11 in the Ly-1 B cell lineageHeavy-chain class switch does not terminate somatic mutation.Mutational hot spots in Ig V region genes of human follicular lymphomasNormal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes.Alternative V kappa gene rearrangements in a murine B cell lymphoma. An explantation for idiotypic heterogeneity.
P2860
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P2860
Evolutionary and somatic selection of the antibody repertoire in the mouse.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Evolutionary and somatic selection of the antibody repertoire in the mouse.
@en
Evolutionary and somatic selection of the antibody repertoire in the mouse.
@nl
type
label
Evolutionary and somatic selection of the antibody repertoire in the mouse.
@en
Evolutionary and somatic selection of the antibody repertoire in the mouse.
@nl
prefLabel
Evolutionary and somatic selection of the antibody repertoire in the mouse.
@en
Evolutionary and somatic selection of the antibody repertoire in the mouse.
@nl
P356
P1433
P1476
Evolutionary and somatic selection of the antibody repertoire in the mouse
@en
P2093
K Rajewsky
P304
P356
10.1126/SCIENCE.3317826
P407
P577
1987-11-01T00:00:00Z