Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid.
about
IMP dehydrogenase: structure, mechanism, and inhibition.Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factorsRegulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast.MDR1-mediated drug resistance in Candida dubliniensisThe transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicansThe transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicansThe antibiotic potential of prokaryotic IMP dehydrogenase inhibitorsDifferential expression of the NRG1 repressor controls species-specific regulation of chlamydospore development in Candida albicans and Candida dubliniensis.A yeast model for target-primed (non-LTR) retrotranspositionGene overexpression/suppression analysis of candidate virulence factors of Candida albicans.Environmental induction of white-opaque switching in Candida albicans.An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicansMolecular genetic techniques for gene manipulation in Candida albicans.SAGA/ADA complex subunit Ada2 is required for Cap1- but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infectionPseudohyphal regulation by the transcription factor Rfg1p in Candida albicansThe transcriptional regulator Nrg1p controls Candida albicans biofilm formation and dispersionTransformation systems of non-Saccharomyces yeasts.Factors supporting cysteine tolerance and sulfite production in Candida albicansGlobal transcriptome sequencing identifies chlamydospore specific markers in Candida albicans and Candida dubliniensisImpact of antimicrobial dosing regimen on evolution of drug resistance in vivo: fluconazole and Candida albicans.Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1.The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatinMolecular genetic and genomic approaches to the study of medically important fungiMilestones in Candida albicans gene manipulation.New Clox Systems for rapid and efficient gene disruption in Candida albicans.Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1.Candida albicans adhesin Als3p is dispensable for virulence in the mouse model of disseminated candidiasisDifferential activation of a Candida albicans virulence gene family during infection.Calcineurin is essential for virulence in Candida albicans.Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis.Investigating the function of Ddr48p in Candida albicansAdaptive evolution of drug targets in producer and non-producer organisms.A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.Roles of different peptide transporters in nutrient acquisition in Candida albicansInactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulence.KEX2 influences Candida albicans proteinase secretion and hyphal formation.Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains.Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains.
P2860
Q24642299-67CBF9FC-367F-4CD2-BF3D-130BA183131CQ24670154-8C16ABED-65CD-44C6-AC15-E120CC0DF3C9Q27939514-893489EE-C8F6-412C-98C4-8AB737159FF4Q28364120-07FE7275-610F-4E4A-985C-4C658BB32961Q28469346-EB420226-D781-4634-BAA0-889D4F7D052CQ28477254-9785AD55-9491-4FD4-A5BB-A2D6E7E6B528Q30356398-BA772AB7-F51B-449F-B80C-319A8B048BEEQ31142376-550CA0FB-958D-4FF1-B1A9-73EF0FEA2BCCQ33293405-35402F80-4E44-4AD0-B8C5-DDC616E47612Q33313469-45C56808-7E91-4831-B66A-D6A61C90E7FAQ33343437-8E9D0197-C64D-4290-9033-C17695ABBA5FQ33559158-96FBFF6B-CBCE-4DED-B02A-8BD08293C43FQ33779105-18ABAAF0-1316-4F7A-8D39-4B6A34DB471BQ34057364-75A2AEA6-0D8D-4B1F-9603-C0E7BEC388B5Q34117682-11665D3D-0A61-4F5C-90EF-C5156C4352D6Q34118913-57D223E1-676A-4B00-BC3F-DC12F348E7EAQ34177651-91B9E4AD-85E1-41AD-ACB2-24E3896E9761Q34400716-5C3C9DC2-EFB2-4702-9B99-6F4ED5257B2DQ34589300-A1D62D79-1E75-42BD-BAA2-1C26BA33CE43Q34685442-CEFC1878-19EF-41A3-8FAA-E30DB5279F4CQ34721695-2C7264B9-8D1B-46AD-B887-1690994981C5Q34932227-C7B1DCC2-0C1E-42DF-B083-56986C30C89EQ34932972-A45ECB63-F75E-4FA3-9E06-203F319DD09DQ35034408-67596FF3-88ED-42B1-810F-F21E888CF0BEQ35110690-4EFDCA2B-A937-481F-BE72-94C411C0363AQ35127111-CD6AD6F6-B112-4D65-8BA4-9D91E46DF311Q35190223-4C44B863-E9F1-4B35-8217-5918E0863DFEQ35191806-B7898EB6-59F3-4573-BFD7-6829C6685B58Q35199199-7CF39601-3032-46BA-A865-94F88AC61537Q35761012-ADD1F872-71EC-41AD-A7AC-1D03428380FFQ35801865-90EBED81-A962-4E79-B6CB-4482BC814385Q35802252-37453D43-5AE0-4B68-B2BA-0AAF68E48DFDQ36017815-D02E8622-63B3-428D-90EB-75F883F7EB3EQ36258978-F019EEB3-7C41-4A62-A56F-1EC0F2E1087AQ36746995-9A7D1EEF-85FF-4D2F-BD18-AFC6ECE39815Q36757912-A3B765F1-BF8F-44FB-98F1-3728024974DDQ36787424-5FD69ED2-706D-4C3C-8DD5-43A6D7D909C3Q36889917-3B906E3E-A452-4F54-9407-71CC9676B4C7Q36993519-F4C75250-3851-4B70-AC47-8461218BAE51Q37183937-8086E31C-091B-4DA9-9AE6-682E3C5EDC99
P2860
Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Overexpression of a cloned IMP ...... c inhibitor mycophenolic acid.
@en
Overexpression of a cloned IMP ...... c inhibitor mycophenolic acid.
@nl
type
label
Overexpression of a cloned IMP ...... c inhibitor mycophenolic acid.
@en
Overexpression of a cloned IMP ...... c inhibitor mycophenolic acid.
@nl
prefLabel
Overexpression of a cloned IMP ...... c inhibitor mycophenolic acid.
@en
Overexpression of a cloned IMP ...... c inhibitor mycophenolic acid.
@nl
P2093
P2860
P1476
Overexpression of a cloned IMP ...... c inhibitor mycophenolic acid.
@en
P2093
P2860
P304
P356
10.1128/JB.179.7.2331-2338.1997
P577
1997-04-01T00:00:00Z