A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.
about
Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIPIntracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domainInhibition of nutlin-resistant HDM2 mutants by stapled peptidesIn vitro selection of mutant HDM2 resistant to Nutlin inhibitionExploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growthNanosensing protein allostery using a bivalent mouse double minute two (MDM2) assayA novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53Deconstructing nucleotide binding activity of the Mdm2 RING domain.Binding of Translationally Controlled Tumour Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3.MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapyHomozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death.Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.Avoiding drug resistance through extended drug target interfaces: a case for stapled peptidesInhibitors of MDM2 and MDMX: a structural perspective.Regulation of transcriptional activators by DNA-binding domain ubiquitination.Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops.Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway.
P2860
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P2860
A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
A function for the RING finger ...... DM2 conformation and activity.
@en
A function for the RING finger ...... DM2 conformation and activity.
@nl
type
label
A function for the RING finger ...... DM2 conformation and activity.
@en
A function for the RING finger ...... DM2 conformation and activity.
@nl
prefLabel
A function for the RING finger ...... DM2 conformation and activity.
@en
A function for the RING finger ...... DM2 conformation and activity.
@nl
P2093
P2860
P356
P1476
A function for the RING finger ...... DM2 conformation and activity.
@en
P2093
Alicja Zylicz
Erin Worrall
Janice Bramham
Kathryn L Ball
Susanne Pettersson
Ted R Hupp
P2860
P304
11517-11530
P356
10.1074/JBC.M809294200
P407
P577
2009-02-02T00:00:00Z