Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells. - Wikidata - wikimedia - TriplyDB

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.

http://www.wikidata.org/entity/Q39896274

about

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors.Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines.Halofuginone enhances the radiation sensitivity of human tumor cell lines In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.Gαi3 nuclear translocation causes irradiation resistance in human glioma cells.CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.New insights into checkpoint kinase 1 in the DNA damage response signaling network.Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.DNA repair: the culprit for tumor-initiating cell survival?Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo.Identification of novel inhibitors of human Chk1 using pharmacophore-based virtual screening and their evaluation as potential anti-cancer agents.A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells.Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.BRCA/Fanconi anemia pathway implicates chemoresistance to gemcitabine in biliary tract cancer.Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma.Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776 Autophagy and cancer.Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: a review Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

P2860

Q24657439-DF709854-1ED5-4320-B35E-6C7315AA0C91 Q26745686-5E741E24-AE50-443D-A4CC-70E9BB71830E Q28066320-939E845E-E453-43AF-B7D9-C8E8BAA33B5A Q28078268-F1C1C411-7468-4B81-A92B-A36073530AD0 Q28396027-F87AD762-6F1C-47A3-ABEE-F9E2E00C370F Q28543464-947A6BE1-C413-4DFA-97CD-7B1D5D93501B Q30540593-69DAD8B4-8343-46DA-B34A-8A147A8777EA Q30570001-F3083D5C-0DE3-4E11-8017-8E4E8CFD8F75 Q30584974-89BBC3A4-2055-4B65-AA10-028174974024 Q33441161-FD53FD72-39EA-4DB3-92F7-2D6338108953 Q33692397-78723A16-7B62-45D5-9ACE-8755407A270D Q33717031-580D453B-C091-4645-8186-F0ADFA92B9EB Q33775399-DD8C866E-1E77-4175-85FF-D4D001B83F9B Q33798731-797058B0-F036-4A8B-B690-1730756EB89B Q33815609-A2070BBC-FF4A-4D56-AF22-482A9F7D2536 Q33926817-AAD0FE6D-3F2F-4DB6-9773-47610C240B4A Q34129155-100480CA-A69D-45CD-A04B-1881B9EB6221 Q34154791-6D6D369F-F861-447A-9AA0-D36D43AE1784 Q34204273-2C46E32E-7531-4E07-AB6D-A6159C5B6CA0 Q34273832-CEB0BA2C-4E55-467D-BCD4-662E9372318D Q34287982-1A9EDDAD-EFEF-4311-B656-5400DED4FE52 Q34804212-6A6A8DD1-86D5-4243-8D4C-3881CF2ED94C Q35023976-528355E6-F739-4C63-9CDA-A79FE45307A7 Q35073758-12EE7729-57B9-4CD6-8BE2-EBED2C9B7D64 Q35329233-72B070D8-5EE4-46F1-A8C0-2292FB117EE5 Q35537834-84948D1F-1933-44AE-A6C5-133777131FF9 Q35637224-DB7D2393-6B48-4733-85C6-34949F9549A9 Q35674192-F5BA2D7E-3C86-49AB-9C01-A02600C2DCC1 Q36088183-C19A5B53-0615-4637-811C-39D48246AD54 Q36123830-0B246808-13AF-498F-9F98-869377D19BDC Q36255484-997BB1E2-24DA-4044-BAC8-A7C88066286B Q36309585-ADFDC661-6141-4302-B0A1-19345F2FD989 Q36792626-DECC7A00-BC3F-4C97-A0CE-7B1093D223AE Q36838392-997A4C76-206C-4CF2-A8ED-34C117847F1C Q36941455-771D5FFC-99AD-4E18-AD34-A6A67FB99456 Q37033657-5624A886-7FFE-4CCA-A2D3-0247373ECEE7 Q37100166-B8296E5F-151F-4B60-8FCD-58F3EF27D3CF Q37102158-9DD54934-0603-4117-B45A-F081B3D507FB Q37230970-0B1CB426-9DF4-48D8-BFD7-71174A0FFA59 Q37240588-C4861556-EA26-4B0C-82C4-A292C3B7756E

P2860

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.

http://www.wikidata.org/entity/Q39896274

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

Gemcitabine sensitization by c ...... se in pancreatic cancer cells.

@en

Gemcitabine sensitization by c ...... se in pancreatic cancer cells.

@nl

type

label

Gemcitabine sensitization by c ...... se in pancreatic cancer cells.

@en

Gemcitabine sensitization by c ...... se in pancreatic cancer cells.

@nl

prefLabel

Gemcitabine sensitization by c ...... se in pancreatic cancer cells.

@en

Gemcitabine sensitization by c ...... se in pancreatic cancer cells.

@nl

P1433

Q39896274-5F193749-040F-4134-9866-4EF61A9714EC

P1476

Q39896274-9D4F0AF4-1E37-4E4C-9D1A-ADA315236051

P2093

Q39896274-19811EF9-FDCD-40E5-9D63-16E1958D98D6

Q39896274-26182B37-668E-4AF7-AD05-FF12214F1DBF

Q39896274-34721146-4E42-4A59-BCB8-82465A845DA8

Q39896274-3C6EDF74-E157-4F48-B328-8D982C6CC64E

Q39896274-76E59597-99C0-47B9-BB1D-1535BDCEAB0E

Q39896274-929209CB-86BA-462A-9467-013EED4267C0

Q39896274-D6EBC80F-16A5-4BB1-A91F-6B07B38EC396

Q39896274-F2340FBF-EEAB-4C06-8EB5-64A1361384C4

Q39896274-F7D85B1C-27DB-4166-8956-DACDCB2A48EA

Q39896274-F86ABA7E-27CE-4F4F-B5E6-78600453F71F

P2860

Q39896274-06084428-4C55-4DCD-AEB6-9DA6E0827A99

Q39896274-2694EAE6-3060-4EA2-BDD9-2DE6C96629EE

Q39896274-3384B10F-664A-44AA-B784-B624D775BD19

Q39896274-3A8D5106-CFB4-47D3-8097-D058CEB4DCE5

Q39896274-44A41FD4-CB95-4D17-B58F-5297FCA42F2B

Q39896274-44E6D273-6067-45D7-9454-080BBE5ED096

Q39896274-47EF12A3-8D54-4899-8D44-51F3F4646F31

Q39896274-4F1DCC4B-D8F7-4F7A-B682-F5975B73160C

Q39896274-4F9103D7-9A82-498B-8B4D-7E0972588645

Q39896274-51CE9040-C970-4E2C-AC7D-20D01B90AC2A

P304

Q39896274-AB19ABCC-D725-4667-BA15-0D15A454B54C

P31

Q39896274-C4B51B62-48B3-4B7C-8D37-162D44389BFC

P356

Q39896274-2E41443A-205B-4D73-BFCD-DC7EC2AB5518

P433

Q39896274-FB1F5ABC-5FA4-4502-9D31-325DDFB4C5AF

P478

Q39896274-92EB5948-05A7-44D3-821E-83069A2C6872

P577

Q39896274-713E5490-66A4-4537-89E2-6F17EA43734D

P698

Q39896274-6D4217F7-FBBA-481F-853A-3E25D84452C4

P921

Q39896274-C0D34806-FE7E-4594-9CDE-4CB6BD8E711D

P932

Q39896274-631DC67E-FD2E-4C65-9981-B01C794F1198

P356

1535-7163.MCT-08-0662

P1433

Molecular Cancer Therapeutics

P1476

Gemcitabine sensitization by c ...... se in pancreatic cancer cells.

@en

P2093

Alan J Kraker

http://www.w3.org/2001/XMLSchema#string

Brian D Palmer

http://www.w3.org/2001/XMLSchema#string

Christine E Canman

http://www.w3.org/2001/XMLSchema#string

Daria M Tanska

http://www.w3.org/2001/XMLSchema#string

Jonathan Maybaum

http://www.w3.org/2001/XMLSchema#string

Joshua D Parsels

http://www.w3.org/2001/XMLSchema#string

Leslie A Parsels

http://www.w3.org/2001/XMLSchema#string

Meredith A Morgan

http://www.w3.org/2001/XMLSchema#string

R John Booth

http://www.w3.org/2001/XMLSchema#string

Theodore S Lawrence

http://www.w3.org/2001/XMLSchema#string

P2860

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Chk1 inhibitors for novel cancer treatment

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics

Identification of pancreatic cancer stem cells

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

P304

45-54

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/1535-7163.MCT-08-0662

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

8

http://www.w3.org/2001/XMLSchema#string

P577

2009-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19139112

http://www.w3.org/2001/XMLSchema#string

P921

P932

2730564

http://www.w3.org/2001/XMLSchema#string