Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice. - Wikidata - wikimedia - TriplyDB

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

http://www.wikidata.org/entity/Q39984604

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VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'.An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.Mobilization of RAG-generated signal ends by transposition and insertion in vivo Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes The RAG2 C terminus suppresses genomic instability and lymphomagenesis.RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination.A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair Evidence for Ku70/Ku80 association with full-length RAG1.53BP1 facilitates long-range DNA end-joining during V(D)J recombination.RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.How does DNA break during chromosomal translocations?V(D)J Recombination: Mechanism, Errors, and Fidelity.Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures.Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency.RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.Reassignment of the murine 3'TRDD1 recombination signal sequence.iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity.Rag mutations reveal robust alternative end joining

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P2860

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

http://www.wikidata.org/entity/Q39984604

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh

2004年學術文章

@zh-hant

name

Increased frequency of aberrant V

@nl

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

@en

type

label

Increased frequency of aberrant V

@nl

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

@en

prefLabel

Increased frequency of aberrant V

@nl

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

@en

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Nucleic Acids Research

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Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

@en

P2093

Darryll D Dudley

http://www.w3.org/2001/XMLSchema#string

Frederick W Alt

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Sadiqur R Talukder

http://www.w3.org/2001/XMLSchema#string

Yoshiko Akamatsu

http://www.w3.org/2001/XMLSchema#string

Yousuke Takahama

http://www.w3.org/2001/XMLSchema#string

P2860

DNA end-joining catalyzed by human cell-free extracts

The RAG1 N-terminal domain is an E3 ubiquitin ligase

Nonhomologous end joining and V(D)J recombination require an additional factor

A functional analysis of the spacer of V(D)J recombination signal sequences

A simple salting out procedure for extracting DNA from human nucleated cells

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

Expression and V(D)J recombination activity of mutated RAG-1 proteins

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4539-4549

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scholarly article

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10.1093/NAR/GKH778

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15

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32

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2004-08-24T00:00:00Z

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15328366

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516053

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