Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.
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Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patensNucleases in homologous recombination as targets for cancer therapyThe convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancerDNA Polymerase θ: A Unique Multifunctional End-Joining MachineThe response to and repair of RAG-mediated DNA double-strand breaksHomology and enzymatic requirements of microhomology-dependent alternative end joiningATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksDouble strand break repair functions of histone H2AXRole of mammalian Mre11 in classical and alternative nonhomologous end joiningDual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Limiting the persistence of a chromosome break diminishes its mutagenic potential.RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Cdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to cell cycle progressionHistone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationThe Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevisDual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy.Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.Origin of chromosomal translocations in lymphoid cancer.Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.Mechanisms of double-strand break repair in somatic mammalian cells.Targeting abnormal DNA double strand break repair in cancer53BP1 promotes microhomology-mediated end-joining in G1-phase cells.H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombinationATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.The RAG2 C terminus suppresses genomic instability and lymphomagenesis.Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathwayPIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joiningBRCA1 Mutation: A Predictive Marker for Radiation Therapy?Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks.CtIP promotes microhomology-mediated alternative end joining during class-switch recombinationDefining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
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Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Roles for NBS1 in alternative nonhomologous end-joining of V
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Roles for NBS1 in alternative ...... J recombination intermediates.
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type
label
Roles for NBS1 in alternative nonhomologous end-joining of V
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Roles for NBS1 in alternative ...... J recombination intermediates.
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prefLabel
Roles for NBS1 in alternative nonhomologous end-joining of V
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Roles for NBS1 in alternative ...... J recombination intermediates.
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P2860
P50
P1433
P1476
Roles for NBS1 in alternative ...... )J recombination intermediates
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P2093
Annalee Baker
David B Roth
P2860
P356
10.1016/J.MOLCEL.2009.03.009
P577
2009-04-01T00:00:00Z