DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
about
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationDYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeDissecting Alzheimer disease in Down syndrome using mouse modelsNeurological phenotypes for Down syndrome across the life spanTau and tauopathiesStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognitionβ-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sitesDesign and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitorsEffect of Ca2+ on the microtubule-severing enzyme p60-katanin. Insight into the substrate-dependent activation mechanismA chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibitionSelective inhibition of the kinase DYRK1A by targeting its folding processDYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort.High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.Roles of tau protein in health and disease.Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytesEvaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.Bioactive marine drugs and marine biomaterials for brain diseasesPhosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegenerationDyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.Pharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) inhibitorsThe role of DYRK1A in neurodegenerative diseases.Survival and morbidity outcomes for very low birth weight infants with Down syndromeREST regulates DYRK1A transcription in a negative feedback loop.Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndromeDown syndrome--recent progress and future prospects.Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing.Dyrk1A Positively Stimulates ASK1-JNK Signaling Pathway during Apoptotic Cell Death.Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease.Altered regulation of tau phosphorylation in a mouse model of down syndrome agingAbnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal lossDown syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.A rare de novo duplication of chromosome 21q22.12 → q22.3 with other concomitant deletion and duplication of small fragments in 21q associated with Down syndrome: Prenatal diagnosis, molecular cytogenetic characterizationOverexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome.The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.Alzheimer's Disease in Adults with Down SyndromeNegative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis.
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P2860
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
DYRK1A-mediated hyperphosphory ...... yndrome and Alzheimer disease.
@en
type
label
DYRK1A-mediated hyperphosphory ...... yndrome and Alzheimer disease.
@en
prefLabel
DYRK1A-mediated hyperphosphory ...... yndrome and Alzheimer disease.
@en
P2093
P2860
P921
P356
P1476
DYRK1A-mediated hyperphosphory ...... yndrome and Alzheimer disease.
@en
P2093
Chinzorig Radnaabazar
Hey Kyeong Jeong
Hye-Won Lee
Hyun-Jeong Cho
In-Sook Kim
Jin-Ju Yoo
Soo-Ryoon Ryoo
Sul-Hee Chung
Woo-Joo Song
Young Soo Ahn
P2860
P304
34850-34857
P356
10.1074/JBC.M707358200
P407
P577
2007-09-28T00:00:00Z