Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating.
about
Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channelsA recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsMolecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine MyocardiumThe subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domainsMolecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.An Interdomain KCNH2 Mutation Produces an Intermediate Long QT SyndromeRole of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.The EGFP/hERG fusion protein alter the electrophysiological properties of hERG channels in HEK293 cells.hERG potassium channel gating is mediated by N- and C-terminal region interactionsDemonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channelC-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel TraffickingNegative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes.The eag domain regulates hERG channel inactivation gating via a direct interaction.hERG gating microdomains defined by S6 mutagenesis and molecular modeling.Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.Cytoplasmic domains and voltage-dependent potassium channel gating.HERG potassium channel regulation by the N-terminal eag domain.Voltage-dependent gating of HERG potassium channels.The enigmatic cytoplasmic regions of KCNH channels.Kv10.1 K(+) channel: from physiology to cancer.Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.Effects of Temperature on Heteromeric Kv11.1a/1b and Kv11.3 ChannelsDifferences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating.Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit.Specificity of TRH receptor coupling to G-proteins for regulation of ERG K+ channels in GH3 rat anterior pituitary cells.Relevance of the proximal domain in the amino-terminus of HERG channels for regulation by a phospholipase C-coupled hormone receptor.Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions.The functional properties of the human ether-à-go-go-like (HELK2) K+ channel.Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region.Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed.Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains.Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels.Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.Roles of PKC Isoforms in PMA-Induced Modulation of the hERG Channel (Kv11.1).Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain.
P2860
Q24301043-DB4F984F-BFC8-4E1E-8D37-A5B66DEAC72BQ24655800-B3E0378A-C73C-4D9A-ABAB-754B6CCDD845Q28548072-24A35270-E343-46DD-87E9-2D824B8FA93FQ28568486-B2848A1E-6A33-46C9-A985-46DA61F71A7DQ30474096-84B01C26-4643-4D18-B0B6-78CFD8C7221AQ33165658-2061B215-9DD9-4DCD-8953-E3A21F691247Q33619341-8B21FC0D-3AAC-44E9-9974-3A3FAF51C656Q33766430-DF1D7C32-CA2C-49A6-8CFD-7E55A889129DQ34618908-08A698A3-7CCC-42AE-9A06-58DB1C702F42Q34998277-5AC449B5-2546-49BD-A9D9-5EF7C20CEF37Q35034968-72A093BD-6D4F-4550-B22B-B197F4383D9FQ35874979-6CE2B1BE-52B5-4780-8047-6AB82FE0DD04Q36412430-3D4042D8-1EB4-4D9F-8C71-E69443ED223FQ36568494-CFF7B971-5626-4B99-8398-1F84B83F5A9BQ36946670-4F06DCB9-A88C-408B-B962-384276C13CABQ37385262-92A8407A-C8C0-4583-8302-FDC174831310Q37999317-6950D392-045C-4761-AC9C-D71888076AC3Q38004348-ED8E7679-E384-4B32-911B-795B9E7D9FB3Q38010173-7427AC3A-D538-4518-9CF7-BBDD46D3D4D9Q38243381-84973E56-DF45-43A2-B946-52EC1ABBE7C7Q38690062-37A9C8CF-B22C-4E1D-8DCC-ECCA6E4958DCQ39372227-6F7CB02F-98C4-4ACA-AD79-B7F059BE4BBBQ39504811-ACBB17E3-7213-4B0C-92F8-1C8B684CB4E7Q39850329-04BDE7E6-07F6-4EAA-B996-FC7E2D1FC28FQ40228198-6ECA5684-B9AB-4BEF-AA32-A1D4FA8D378FQ40341709-54E350FA-0106-4BE0-BDDC-44E2BEA90658Q40419988-758697FB-689E-4A72-959B-D350E2632CE3Q40673715-FBA67025-4571-485D-8A3C-FD1D2114206CQ42571483-D0D6C097-4C88-4481-B9AA-A95CFB0955B8Q42628734-7F17C7B4-00BB-43E6-B1B2-1B2346D8BC5FQ42683368-06503BA3-38BF-4343-BA2D-C204208F94BBQ43205719-0CA502C5-618B-4BD6-879D-A1544D7C1BA4Q44112587-1E9B7D53-6E27-42FF-9216-743B53C9BD45Q44213450-75BEFF72-E315-4C1F-B47A-5FF30094C758Q46705938-40AF7065-71FA-49DD-8CEF-7A9EC6FD9E85Q47261912-818C2251-240F-40C1-AC82-BCF551701FB6Q48630181-A1C45FAB-3064-4CB0-9196-2BA72CD52964Q50192004-4F521E99-38EA-4DB6-B666-0E4105F8B680Q51119613-82E942A5-0607-445D-8FB6-EF3714AC1659Q55385752-5B80CCE2-D15F-4E2B-8700-A261ACA5DF95
P2860
Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Differential effects of amino- ...... human erg K(+) channel gating.
@en
type
label
Differential effects of amino- ...... human erg K(+) channel gating.
@en
prefLabel
Differential effects of amino- ...... human erg K(+) channel gating.
@en
P2093
P2860
P1433
P1476
Differential effects of amino- ...... human erg K(+) channel gating
@en
P2093
C G Viloria
D Gómez-Varela
P de la Peña
P2860
P304
P356
10.1016/S0006-3495(00)76286-2
P407
P577
2000-07-01T00:00:00Z