Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. - Wikidata - wikimedia - TriplyDB

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

http://www.wikidata.org/entity/Q40252256

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Monoubiquitylation promotes mitochondrial p53 translocation Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts PUMA, a potent killer with or without p53 Molecular signatures associated with ZIKV exposure in human cortical neural progenitors Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection Functional analysis of Hsp70 inhibitors The p53 pathway as a target in cancer therapeutics: obstacles and promise Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness The Roles of Syncytin-Like Proteins in Ruminant Placentation Necrostatin-1 rescues mice from lethal irradiation Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition Hsp70-Bag3 interactions regulate cancer-related signaling networks HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy.Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation A high-throughput screen for alpha particle radiation protectants.Targeting p53 for Novel Anticancer Therapy.BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain.p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity An anti-apoptotic peptide improves survival in lethal total body irradiation.p53 and mitochondrial function in neurons.Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation Pathologies associated with the p53 response.Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.Protein chaperones: a composition of matter review (2008 - 2013).Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis.Autophagy-regulating small molecules and their therapeutic applications.The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities.Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21).

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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

http://www.wikidata.org/entity/Q40252256

description

2006 nî lūn-bûn

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Small-molecule inhibitor of p5 ...... cts mice from gamma radiation.

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Small-molecule inhibitor of p5 ...... cts mice from gamma radiation.

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Small-molecule inhibitor of p5 ...... cts mice from gamma radiation.

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Nature Chemical Biology

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Small-molecule inhibitor of p5 ...... cts mice from gamma radiation.

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P2093

Dmitry A Bosykh

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Elena A Komarova

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Evguenia Strom

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Inna Shyshynova

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Ivanda Pavlovska

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Lyudmila G Burdelya

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Olga B Chernova

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Pavel G Komarov

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Rami Skaliter

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Roger M Macklis

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P2860

p53 has a direct apoptogenic role at the mitochondria

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

p53 is required for radiation-induced apoptosis in mouse thymocytes

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos.

Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells.

Could p53 be a target for therapeutic suppression?

Twenty years of p53 research: structural and functional aspects of the p53 protein.

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.

p53: death star.

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474-479

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scholarly article

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10.1038/NCHEMBIO809

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9

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2

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Andrei V. Gudkov

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2006-07-23T00:00:00Z

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6924245

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1014377287

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16862141

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