Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B.
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von Willebrand factor type D domain mutant of SVS-1/SUSD2, vWD(m), induces apoptosis in HeLa cells.Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds.Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharumSynthesis and Anticancer Activity of Epipolythiodiketopiperazine AlkaloidsSea foam as a source of fungal inoculum for the isolation of biologically active natural products.Gracilaria edulis extract induces apoptosis and inhibits tumor in Ehrlich ascites tumor cells in vivo.G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation.Drugs and drug intermediates from fungi: Striving for greener processes.Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?Concise Total Synthesis of (+)-Luteoalbusins A and B.General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.3EZ,20Ac-ingenol, a catalytic inhibitor of topoisomerases, downregulates p-Akt and induces DSBs and apoptosis of DT40 cells.Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: small molecules with great potentialTargeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapyStructure, bioactivity and synthesis of natural products with hexahydropyrrolo[2,3-b]indole.Dual inhibition: a novel promising pharmacological approach for different disease conditions.Major bioactive metabolites from marine fungi: A Review.Enantioselective synthesis of pyrroloindolines by a formal [3 + 2] cycloaddition reaction.Anticancer effect and structure-activity analysis of marine products isolated from metabolites of mangrove fungi in the South China Sea.Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade.Isolation of a novel mouse gene, mSVS-1/SUSD2, reversing tumorigenic phenotypes of cancer cells in vitro.
P2860
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P2860
Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Leptosins isolated from marine ...... ation of Akt/protein kinase B.
@en
type
label
Leptosins isolated from marine ...... ation of Akt/protein kinase B.
@en
prefLabel
Leptosins isolated from marine ...... ation of Akt/protein kinase B.
@en
P2093
P2860
P1433
P1476
Leptosins isolated from marine ...... ation of Akt/protein kinase B.
@en
P2093
Atsushi Numata
Banri Yamanoha
Izumi Yamashita
Masahito Shinomi
Masashi Hayashida
Miyako Yanagihara
Noriko Sasaki-Takahashi
Seiko Yamamoto
Takao Yamori
Tetsuo Sugahara
P2860
P304
P356
10.1111/J.1349-7006.2005.00117.X
P577
2005-11-01T00:00:00Z