TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. - Wikidata - wikimedia - TriplyDB

TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.

TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.

http://www.wikidata.org/entity/Q40522842

about

3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS The Smad3 linker region contains a transcriptional activation domain Getting 'Smad' about obesity and diabetes Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions Smad3 phospho-isoform signaling in hepatitis C virus-related chronic liver diseases Molecular aspects of development and regulation of endometriosis Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1 Pin1 promotes transforming growth factor-beta-induced migration and invasion.Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis.Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts.TGF-β/Smad signaling during hepatic fibro-carcinogenesis (review).Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.A crosstalk between the Smad and JNK signaling in the TGF-β-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells.Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition.Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle.Phosphorylation of Smad2/3 at specific linker threonine indicates slow-cycling intestinal stem-like cells before reentry to cell cycle.Retinoic acid promotes myogenesis in myoblasts by antagonizing transforming growth factor-beta signaling via C/EBPβ Regulation of TGF-β1-Induced Pro-Apoptotic Signaling by Growth Factor Receptors and Extracellular Matrix Receptor Integrins in the Liver.Smad phosphoisoform signaling specificity: the right place at the right time SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells.Axl activates autocrine transforming growth factor-β signaling in hepatocellular carcinoma Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos.Kaempferol Suppresses Transforming Growth Factor-β1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179.Phospho-specific Smad3 signaling: impact on breast oncogenesis.Bone Morphogenetic Protein-9 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via the JNK Pathway.c-Jun N-terminal kinase inhibitor favors transforming growth factor-β to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma Roles of Smad3 in TGF-beta signaling during carcinogenesis.Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter.To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications

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P2860

TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.

http://www.wikidata.org/entity/Q40522842

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2004 nî lūn-bûn

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Fukiko Furukawa

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Go Sekimoto

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Hideo Yamagata

http://www.w3.org/2001/XMLSchema#string

Hirofumi Matsui

http://www.w3.org/2001/XMLSchema#string

Jun-ichi Fujisawa

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Katsunori Yoshida

http://www.w3.org/2001/XMLSchema#string

Kazuichi Okazaki

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Koichi Matsuzaki

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Mikio Nishizawa

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Shigeo Mori

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P2860

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

Mitogen-activated protein kinase pathways

TGF-beta signaling: positive and negative effects on tumorigenesis.

Environmental-dependent acceleration of a developmental switch: the floral transition.

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues

Type beta transforming growth factor: a bifunctional regulator of cellular growth

Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells.

Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts.

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

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7416-7429

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10.1038/SJ.ONC.1207981

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44

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23

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1005317480

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15326485

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phosphorylation