Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.
about
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor modelActive-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent mannerC5L2 is a functional receptor for acylation-stimulating proteinKinetic mechanism of AKT/PKB enzyme familyHeat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator ProteinDNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survivalA role of DNA-PK for the metabolic gene regulation in response to insulinA pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingSIRT6 in DNA repair, metabolism and ageingIdentification of Sin1 as an essential TORC2 component required for complex formation and kinase activityRegulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glancePI3K-PKB/Akt pathwayTurning off AKT: PHLPP as a drug targetPosttranslational regulation of Akt in human cancerPhosphatidylinositol 3-kinase mutations identified in human cancer are oncogenicReconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast.RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damageHeat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair fociPI3K-independent AKT activation in cancers: a treasure trove for novel therapeuticsIdentification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cellsRole of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibitionImatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulationTargeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasionPKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells.Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation.Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responsesDifferential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.Deletion of PKBalpha/Akt1 affects thymic developmentPDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing.Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo.A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
P2860
Q21133610-22CD6C7E-46DB-493B-B3A5-03C0E28D9643Q21145847-18EA5EDD-FD28-47E7-BA2E-22D1BA1A6175Q24297392-09B7A87E-191E-440C-9A87-2465DC1B79FEQ24298269-E10F0327-6E35-40C9-A666-8496AC972DBAQ24300165-07BBEBC1-AFFC-4F76-A9DF-37D8CEE63631Q24307898-F7F0A7C2-939C-40D5-A7BA-2E2FA385DCEBQ24314764-CC6DE95F-DCB2-4480-88A9-A20A8F936291Q24316008-ABFE3DA9-768F-451E-BAD5-E21B4E92518FQ24323112-D1F0CEE7-E668-4B0E-8D8E-ABAD0428D0CBQ24599676-E73910F4-45E5-4AAD-9E46-B76DCDE4CE2CQ24653962-7622ADC8-282D-41C8-A76A-77CE84F2091DQ24680264-34A6EB9D-4A45-4AEB-91AC-114DF63A5C28Q26764871-9D1EA57F-6669-4EF8-ACDE-E520906B26F1Q26829696-10DAC18F-C6C6-4668-ADEB-D0FA7DA892FFQ27014094-CA1DBE16-276E-4F8A-AE1B-689953B64FBFQ27027815-1E2D4A4B-5D3C-496D-9BDD-9CFC883887D9Q27824826-2F69F70C-3F2B-40C1-85CB-9CB11971CE95Q27933247-F6BCA871-134D-4480-9542-E152616DC651Q28116209-B4660A05-1BAE-43B1-8D85-E3C818232A5FQ28257991-39DD6A2D-14DB-4397-92FB-8C04FC6E43D2Q28259003-B4186BCD-6768-495E-9CF1-BA9E796798A8Q28285843-D58DB00C-F8A8-44C2-8F19-E711EA1E3DDDQ28474624-D1451406-2267-421B-8254-63F03EDB6651Q28485861-D8E177F3-05D9-40C5-979B-298B70736F6CQ28535408-E537F34B-21DB-412E-8203-C85BB19AEF7DQ28550300-BB48CDF6-55F9-4EE7-AA9C-C27E53011A7BQ28771765-32E530C4-4C4C-489B-BA49-095E153F976DQ30434675-DE2D2484-8681-4A25-8217-0D9F5C8E6C50Q30436921-7D03DDF8-382B-4231-83EF-F1DABA45205EQ30478648-E33E2CA9-C98A-4715-9D8F-AF6618709FF0Q30537866-57DF6B80-86B8-408F-AD8B-A98C4F67F090Q33234136-21514D0A-4C5B-4801-BA43-D2B10140925CQ33301344-F55A0AD7-14A6-4683-8DB9-AE746089C855Q33341346-8BC87D21-CFA0-4468-BDFC-7498643D7338Q33398848-EAE150F9-C0AF-4946-A587-076270F585FAQ33447106-2AE382FF-A454-4E3E-ADA9-0EED3164BADCQ33537400-55191F19-1147-435C-97CF-C6EC7F430843Q33602622-417FBF02-A311-44DF-9094-C7107A19C3B5Q33655527-2ECA73E5-6AB6-40A2-A0D3-7C44A85786E2Q33707181-FC9F56D2-9244-46C2-8C29-1075A17379AE
P2860
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Identification of a PKB/Akt hy ...... DNA-dependent protein kinase.
@en
type
label
Identification of a PKB/Akt hy ...... DNA-dependent protein kinase.
@en
prefLabel
Identification of a PKB/Akt hy ...... DNA-dependent protein kinase.
@en
P2093
P356
P1476
Identification of a PKB/Akt hy ...... DNA-dependent protein kinase.
@en
P2093
Brian A Hemmings
Daniel Hess
Jianhua Feng
Peter Cron
P304
41189-41196
P356
10.1074/JBC.M406731200
P407
P50
P577
2004-07-15T00:00:00Z