Neuroactive steroids have multiple actions to potentiate GABAA receptors.
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Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-olStructural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptorNeurosteroids: endogenous regulators of the GABA(A) receptorBeyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and EmotionKinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptorsNeurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.Ganaxolone.11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.Mechanisms of neurosteroid interactions with GABA(A) receptors.Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetatealpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids.Neurosteroids, stress and depression: potential therapeutic opportunities.Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors.Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of gamma-aminobutyric acid type A receptors.The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor.Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABA(A) receptors.Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses.Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.The sticky issue of neurosteroids and GABA(A) receptors.Modes and models of GABA(A) receptor gating.An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits.Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue.Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.A neurosteroid potentiation site can be moved among GABAA receptor subunits.Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.
P2860
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P2860
Neuroactive steroids have multiple actions to potentiate GABAA receptors.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Neuroactive steroids have multiple actions to potentiate GABAA receptors.
@en
type
label
Neuroactive steroids have multiple actions to potentiate GABAA receptors.
@en
prefLabel
Neuroactive steroids have multiple actions to potentiate GABAA receptors.
@en
P2093
P2860
P1476
Neuroactive steroids have multiple actions to potentiate GABAA receptors.
@en
P2093
Alex Evers
Douglas F Covey
Gustav Akk
Joe Henry Steinbach
John R Bracamontes
P2860
P356
10.1113/JPHYSIOL.2004.066571
P407
P577
2004-05-14T00:00:00Z