Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling. - Wikidata - wikimedia - TriplyDB

Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.

Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.

http://www.wikidata.org/entity/Q40637759

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G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia Protein tyrosine phosphatases in the JAK/STAT pathway Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer.Interleukin-3 receptor in acute leukemia.A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells.Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury.A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors.Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay.Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies SHP-2 tyrosine phosphatase in human diseases.Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice.Helicobacter pylori CagA: a critical destroyer of the gastric epithelial barrier.Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-β production.Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability.Gab adapter proteins as therapeutic targets for hematologic disease.Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.The Helicobacter pylori virulence factor CagA promotes Erk1/2-mediated Bad phosphorylation in lymphocytes: a mechanism of CagA-inhibited lymphocyte apoptosis.Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.Complex systems biology approach to understanding coordination of JAK-STAT signaling.Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells.SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively.Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling.Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia.Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.

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P2860

Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.

http://www.wikidata.org/entity/Q40637759

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2003 nî lūn-bûn

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Catalytic-dependent and -indep ...... se in interleukin-3 signaling.

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Catalytic-dependent and -indep ...... se in interleukin-3 signaling.

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Catalytic-dependent and -indep ...... se in interleukin-3 signaling.

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Catalytic-dependent and -indep ...... se in interleukin-3 signaling.

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Cheng-Kui Qu

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Robert G Hawley

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Teresa S Hawley

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Wen-Mei Yu

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P2860

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes

Engagement of Gab1 and Gab2 in erythropoietin signaling

p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells

Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor

SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates

Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response.

Combinatorial control of the specificity of protein tyrosine phosphatases.

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases.

JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells.

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10.1038/SJ.ONC.1206846

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38

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22

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2003-09-01T00:00:00Z

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12955078

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