Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.
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G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemiaProtein tyrosine phosphatases in the JAK/STAT pathwayProtein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stabilityInhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAPIdentification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer.Interleukin-3 receptor in acute leukemia.A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorderProtein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells.Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury.A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinomaTLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors.Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay.Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignanciesSHP-2 tyrosine phosphatase in human diseases.Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice.Helicobacter pylori CagA: a critical destroyer of the gastric epithelial barrier.Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-β production.Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability.Gab adapter proteins as therapeutic targets for hematologic disease.Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.The Helicobacter pylori virulence factor CagA promotes Erk1/2-mediated Bad phosphorylation in lymphocytes: a mechanism of CagA-inhibited lymphocyte apoptosis.Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.Complex systems biology approach to understanding coordination of JAK-STAT signaling.Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells.SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively.Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling.Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia.Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
P2860
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P2860
Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Catalytic-dependent and -indep ...... se in interleukin-3 signaling.
@en
type
label
Catalytic-dependent and -indep ...... se in interleukin-3 signaling.
@en
prefLabel
Catalytic-dependent and -indep ...... se in interleukin-3 signaling.
@en
P2093
P2860
P356
P1433
P1476
Catalytic-dependent and -indep ...... se in interleukin-3 signaling.
@en
P2093
Cheng-Kui Qu
Robert G Hawley
Teresa S Hawley
Wen-Mei Yu
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206846
P407
P577
2003-09-01T00:00:00Z
P5875
P6179
1001050799