Identification of metabotropic glutamate receptor antagonists using an automated high-throughput screening system.
about
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screeningHigh throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound librariesMultiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screenSmall molecule activators of TRPML3Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screeningAn ultra-high throughput cell-based screen for wee1 degradation inhibitorsA FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screeningAn altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screeningSmall-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.High-throughput screen for pharmacoperones of the vasopressin type 2 receptorDevelopment of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology.Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.An offline-addition format for identifying GPCR modulators by screening 384-well mixed compounds in the FLIPR.
P2860
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P2860
Identification of metabotropic glutamate receptor antagonists using an automated high-throughput screening system.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Identification of metabotropic ...... h-throughput screening system.
@en
type
label
Identification of metabotropic ...... h-throughput screening system.
@en
prefLabel
Identification of metabotropic ...... h-throughput screening system.
@en
P2093
P1476
Identification of metabotropic ...... h-throughput screening system.
@en
P2093
Berta Strulovici
Bradley Feuston
Carla Suto
Chris Bayly
Chris Culberson
James Inglese
Jason Cassaday
Kurtis Berry
Leo Bleicher
Mark Varney
P304
P356
10.1016/S0003-2697(02)00608-5
P407
P577
2003-02-01T00:00:00Z