Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.
about
Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Multiple roles of vertebrate REV genes in DNA repair and recombinationThe origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expressionSMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repairAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesCloning and functional characterisation of avian transcription factor E2AActivation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateGenetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell lineAID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingSimultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesionsAntibody discovery ex vivo accelerated by the LacO/LacI regulatory networkTemporal regulation of Ig gene diversification revealed by single-cell imaging.Rapid generation of specific antibodies by enhanced homologous recombination.DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.Chromatin structure regulates gene conversion.Genetic variation stimulated by epigenetic modification.Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regionsFanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Attracting AID to targets of somatic hypermutation.Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) proteinHigh frequency mitotic gene conversion in genetic hybrids of the oomycete Phytophthora sojaeCutting edge: CTNNBL1 is dispensable for Ig class switch recombination.Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination.Somatic immunoglobulin hypermutation.The chicken as a model for large-scale analysis of vertebrate gene function.Involvement of Rad18 in somatic hypermutationEmerging links between hypermutation of antibody genes and DNA polymerases.Bloom DNA helicase facilitates homologous recombination between diverged homologous sequencesAID and mismatch repair in antibody diversification.Targeting of AID-mediated sequence diversification to immunoglobulin genesComparative analyses of immunoglobulin genes: surprises and portents.Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.Class-switch recombination: after the dawn of AID.The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.Hodgkin lymphoma risk: role of genetic polymorphisms and gene-gene interactions in DNA repair pathways.Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) systemWhat role for AID: mutator, or assembler of the immunoglobulin mutasome?The role of DNA breaks in genomic instability and tumorigenesis.
P2860
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P2860
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Ablation of XRCC2/3 transforms ...... on into somatic hypermutation.
@en
type
label
Ablation of XRCC2/3 transforms ...... on into somatic hypermutation.
@en
prefLabel
Ablation of XRCC2/3 transforms ...... on into somatic hypermutation.
@en
P2093
P356
P1433
P1476
Ablation of XRCC2/3 transforms ...... on into somatic hypermutation.
@en
P2093
Calandrini DM
Neuberger MS
P2888
P304
P356
10.1038/35091100
P407
P577
2001-08-01T00:00:00Z
P6179
1019110575