Contribution of potential EF hand motifs to the calcium-dependent gating of a mouse brain large conductance, calcium-sensitive K(+) channel.
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Gating mechanism of BK (Slo1) channels: so near, yet so farRegulation of bestrophin Cl channels by calcium: role of the C terminusThe RCK2 domain of the human BKCa channel is a calcium sensorBeta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanismsBK channels: multiple sensors, one activation gateStructure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activityZn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain.The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangementsStepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.BK channel activation: structural and functional insightsIon sensing in the RCK1 domain of BK channels.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channelIon channels in smooth muscle: regulators of intracellular calcium and contractility.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channelsMechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channelModulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains.Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels.Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channelsAllosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation siteDivalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity.Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.Molecular mechanisms of BK channel activation.BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.A New Splice Variant of Large Conductance Ca2+-activated K+ (BK) Channel α Subunit Alters Human Chondrocyte Function.Molecular Determinants of BK Channel Functional Diversity and Functioning.Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel.Syntaxin-1A binds to and modulates the Slo calcium-activated potassium channel via an interaction that excludes syntaxin binding to calcium channels.Syntaxin 1A co-associates with native rat brain and cloned large conductance, calcium-activated potassium channels in situ.Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains.Kinetic gating mechanisms for BK channels: when complexity leads to simplicity.BK channel news: full coverage on the calcium bowl.Statistical limits to the identification of ion channel domains by sequence similarity.Potentiation of large conductance, Ca2+-activated K+ (BK) channels by alpha5beta1 integrin activation in arteriolar smooth muscle.Hydrophobic interface between two regulators of K+ conductance domains critical for calcium-dependent activation of large conductance Ca2+-activated K+ channels.
P2860
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P2860
Contribution of potential EF hand motifs to the calcium-dependent gating of a mouse brain large conductance, calcium-sensitive K(+) channel.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Contribution of potential EF h ...... alcium-sensitive K(+) channel.
@en
type
label
Contribution of potential EF h ...... alcium-sensitive K(+) channel.
@en
prefLabel
Contribution of potential EF h ...... alcium-sensitive K(+) channel.
@en
P2860
P1476
Contribution of potential EF h ...... alcium-sensitive K(+) channel.
@en
P2860
P304
P356
10.1111/J.1469-7793.2001.00681.X
P407
P577
2001-06-01T00:00:00Z