Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase
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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptaseFunctional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptaseInsertion of a small peptide of six amino acids into the beta7-beta8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities.Conservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmissionInfluence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domainsCrystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNAMutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1.Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase.Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activityConstruction and characterization of a temperature-sensitive human immunodeficiency virus type 1 reverse transcriptase mutantThe P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activitiesYADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerizationReplication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.RNase H cleavage of the 5' end of the human immunodeficiency virus type 1 genome.Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer.Analysis of human immunodeficiency virus type 1 reverse transcriptase subunit structure/function in the context of infectious virions and human target cells.Domain structure of the human immunodeficiency virus reverse transcriptase.Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain.Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophagesSubunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo.The nature of the N-terminal amino acid residue of HIV-1 RNase H is critical for the stability of reverse transcriptase in viral particles.Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase.Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1.Rice tungro bacilliform virus encodes reverse transcriptase, DNA polymerase, and ribonuclease H activities.Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1.Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimerMutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity.Mutation of the aspartic acid residues of the GDD sequence motif of poliovirus RNA-dependent RNA polymerase results in enzymes with altered metal ion requirements for activity.Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replicationReduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesisFrequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages.RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-templateEvaluation of heterologous vaginal SHIV SF162p4 infection following vaccination with a polyvalent Clade B virus-like particle vaccineMolecular matchmaking: NNRTIs can enhance the dimerization of HIV type 1 reverse transcriptase.A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugsHuman immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.
P2860
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P2860
Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Subunit-selective mutagenesis ...... 51 HIV-1 reverse transcriptase
@en
type
label
Subunit-selective mutagenesis ...... 51 HIV-1 reverse transcriptase
@en
prefLabel
Subunit-selective mutagenesis ...... 51 HIV-1 reverse transcriptase
@en
P2093
P2860
P1433
P1476
Subunit-selective mutagenesis ...... 51 HIV-1 reverse transcriptase
@en
P2093
Le Grice SF
Wohlgensinger B
P2860
P304
P407
P50
P577
1991-12-01T00:00:00Z