Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1.
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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsA polymorphism at position 400 in the connection subdomain of HIV-1 reverse transcriptase affects sensitivity to NNRTIs and RNaseH activityMutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelityWild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidineStructural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switchingDecreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.Genotypic testing for human immunodeficiency virus type 1 drug resistance.The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity.Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.Non-nucleoside reverse transcriptase inhibitors: perspectives on novel therapeutic compounds and strategies for the treatment of HIV infection.A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus.Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.Mutations at codon 184 in simian immunodeficiency virus reverse transcriptase confer resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidineFluorescent dye terminator sequencing methods for quantitative determination of replication fitness of human immunodeficiency virus type 1 containing the codon 74 and 184 mutations in reverse transcriptase.Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase.Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.The impact of the M184V substitution on drug resistance and viral fitness.Retrovirus reverse transcriptases containing a modified YXDD motif.Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors.Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphateApparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.The Genetic Basis of HIV-1 Resistance to Reverse Transcriptase and Protease Inhibitors.Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions.HIV-1 nucleocapsid protein and the secondary structure of the binary complex formed between tRNA(Lys.3) and viral RNA template play different roles during initiation of (-) strand DNA reverse transcription.Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides.Monitoring the emergence of hepatitis B virus polymerase gene variants during lamivudine therapy using the LightCycler.Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase.The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity.Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptaseInitial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptaseHuman immunodeficiency virus type 1: resistance to nucleoside analogues and replicative capacity in primary human macrophages.Quantification of the effects on viral DNA synthesis of reverse transcriptase mutations conferring human immunodeficiency virus type 1 resistance to nucleoside analogues.Development and evaluation of an oligonucleotide ligation assay for detection of drug resistance-associated mutations in the human immunodeficiency virus type 2 pol gene.A role of template cleavage in reduced excision of chain-terminating nucleotides by human immunodeficiency virus type 1 reverse transcriptase containing the M184V mutation.
P2860
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P2860
Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Analysis of mutations at posit ...... immunodeficiency virus type 1.
@ast
Analysis of mutations at posit ...... immunodeficiency virus type 1.
@en
type
label
Analysis of mutations at posit ...... immunodeficiency virus type 1.
@ast
Analysis of mutations at posit ...... immunodeficiency virus type 1.
@en
prefLabel
Analysis of mutations at posit ...... immunodeficiency virus type 1.
@ast
Analysis of mutations at posit ...... immunodeficiency virus type 1.
@en
P2860
P356
P1476
Analysis of mutations at posit ...... immunodeficiency virus type 1.
@en
P2093
P2860
P304
P356
10.1128/AAC.39.7.1624
P407
P577
1995-07-01T00:00:00Z