The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydra
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Iron: a target for the management of Kaposi's sarcoma?Pharmacology of iron transportCellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genesSmall-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cellsIron chelators in photodynamic therapy revisited: synergistic effect by novel highly active thiosemicarbazones.Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol.The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron.Desferrithiocin is a more potent antineoplastic agent than desferrioxamine.Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents.A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activities.Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.Another important function for an old friend! The role of iron in colorectal carcinogenesis.Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.Targeting cancer by binding iron: Dissecting cellular signaling pathwaysGrowth-inhibiting effects of taxol on human liver cancer in vitro and in nude miceDifferential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types.Gallium-containing anticancer compounds.Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.Developing an anticancer copper(II) pro-drug based on the nature of cancer cell and human serum albumin carrier IIA subdomain: mouse model of breast cancer.Iron Chelators and Exogenic Photosensitizers. Synergy through Oxidative Stress Gene Expression.α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's disease.In vitro assessment of the role of DpC in the treatment of head and neck squamous cell carcinoma.
P2860
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P2860
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydra
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The potential of iron chelator ...... naphthylaldehyde benzoyl hydra
@en
type
label
The potential of iron chelator ...... naphthylaldehyde benzoyl hydra
@en
prefLabel
The potential of iron chelator ...... naphthylaldehyde benzoyl hydra
@en
P1433
P1476
The potential of iron chelator ...... thylaldehyde benzoyl hydrazone
@en
P2093
Richardson DR
P304
P407
P577
1997-04-01T00:00:00Z