Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.
about
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977Synthesis of nucleoside phosphate and phosphonate prodrugsProdrugs of phosphonates and phosphates: crossing the membrane barrierAn in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugsKinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191.Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.Probing phospholipase a(2) with fluorescent phospholipid substrates.Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir.Synthesis and antiviral evaluation of SATE-foscarnet prodrugs and new foscarnet-AZT conjugates.Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.Pharmacokinetics of bis(t-butyl-SATE)-AZTMP, a bispivaloylthioethyl prodrug for intracellular delivery of zidovudine monophosphate, in mice.Simultaneous HPLC analysis of hydrophobic prodrugs and their hydrophilic metabolites in biological media without sample preparation. Application to the biotransformation studies of pronucleotides derived from 5-fluorouracil.Electrospray ionization mass spectrometry of serine/alanine conjugated 5'-UMP and 3',5'-dithymidine phosphoramidates.Synthesis of serine/alanine conjugated 3',5'-TpT.Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.
P2860
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P2860
Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Decomposition pathways and in ...... nucleoside 5'-monophosphates.
@en
type
label
Decomposition pathways and in ...... nucleoside 5'-monophosphates.
@en
prefLabel
Decomposition pathways and in ...... nucleoside 5'-monophosphates.
@en
P2093
P356
P1476
Decomposition pathways and in ...... nucleoside 5'-monophosphates.
@en
P2093
Cappellacci L
Franchetti P
Girardet JL
Gosselin G
Grifantini M
La Colla P
Périgaud C
P304
P356
10.1021/JM9507338
P407
P577
1996-05-01T00:00:00Z