Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.
about
A Temporal Model of Human IgE and IgG Antibody FunctionGeneration and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenImmunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Most peripheral B cells in mice are ligand selected.An immunoglobulin mutator that targets G.C base pairs.Stepwise intraclonal maturation of antibody affinity through somatic hypermutationStructural and functional implications of a restricted antibody response to a defined antigenic region on the influenza virus hemagglutinin.Immunoglobulin light chains in medaka (Oryzias latipes)Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies.Protein evolution on rugged landscapes.Age-related development of a heterozygous phenotype in solitary neurons of the homozygous Brattleboro ratProgressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversiVariable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells.A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.Early onset of somatic mutation in immunoglobulin VH genes during the primary immune responseEvolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.Somatic hypermutation of an immunoglobulin mu heavy chain transgene.Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutationMolecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization.Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.Somatic hypermutation shapes the antibody repertoire of memory B cells in humans.Synthesis of abnormal immunoglobulins by hybridomas from autoimmune "viable motheaten" mutant mice.Somatic mutation in constant regions of mouse lambda 1 light chainsCellular choreography in the germinal center: new visions from in vivo imaging.High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination.An atlas of B-cell clonal distribution in the human body.The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartmentThree-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune responseSomatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chainsDerivation and diversification of monoclonal antibodies.Sequence analysis of non-expressed immunoglobulin heavy chain loci in clonally related, somatically mutated hybridoma cells.Integrating B cell lineage information into statistical tests for detecting selection in Ig sequencesEmergence of immunoglobulin variants following treatment of a B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin.Distribution of mutations around rearranged heavy-chain antibody variable-region genes.Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain.Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
P2860
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P2860
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.
@en
type
label
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.
@en
prefLabel
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.
@en
P2860
P1433
P1476
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response
@en
P2093
Sablitzky F
P2860
P304
P356
10.1002/J.1460-2075.1985.TB03635.X
P407
P577
1985-02-01T00:00:00Z