Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase
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Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216Mechanism of activation of protein kinase B by insulin and IGF-1Signal transduction by the Wnt family of ligandsActivation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alphaRole of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulinA-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3betaRegulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signalingWortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reactionGlucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of LangerhansThe Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytesCloning and expression of cDNA encoding protein synthesis elongation factor-2 kinaseSpecific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activationOIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways.Inhibition of phosphatidylinositol 3-kinase stimulates activity of the small-conductance K channel in the CCD.A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction.Gi2-mediated activation of the MAP kinase cascade.Fluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: dissection of intracellular signaling pathwaysConvergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis.Rab5 proteins regulate activation and localization of target of rapamycin complex 1.Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes.PfIRR Interacts with HrIGF-I and Activates the MAP-kinase and PI3-kinase Signaling Pathways to Regulate Glycogen Metabolism in Pinctada fucata.Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.Functions of the C-terminal domain of CTP: phosphocholine cytidylyltransferase. Effects of C-terminal deletions on enzyme activity, intracellular localization and phosphorylation potentialPivotal role of leptin in insulin effects.The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells.Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against.Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation.Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor.Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C.The role of phosphatidylinositide-3-kinase in basal mitogen-activated protein kinase activity and cell survival.Insulin enhances macrophage scavenger receptor-mediated endocytic uptake of advanced glycation end products.Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway.Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.
P2860
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P2860
Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Wortmannin inhibits the effect ...... togen-activated protein kinase
@en
type
label
Wortmannin inhibits the effect ...... togen-activated protein kinase
@en
prefLabel
Wortmannin inhibits the effect ...... togen-activated protein kinase
@en
P2093
P2860
P356
P1433
P1476
Wortmannin inhibits the effect ...... togen-activated protein kinase
@en
P2093
E J Foulstone
J M Tavaré
P2860
P356
10.1042/BJ3030015
P407
P478
303 ( Pt 1)
P577
1994-10-01T00:00:00Z