PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.
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Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylationThe interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signalingUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisGTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitIdentification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gammaRole of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptorAkt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factorA tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1Abl family kinases regulate endothelial barrier function in vitro and in micePhospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for SykPLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migrationIdentification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activationThe selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding siteSH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchangeNucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicityPhospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effectorIdentification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATThe SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatmentPhosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMPGRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulationAutophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60srcFc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cellsTyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activationAnalysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptorsAssociation of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptorThe Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and diseaseSignal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2Phosphoinositides: tiny lipids with giant impact on cell regulationAutoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ IsozymesSustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesisEvidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human plateletsInteraction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activitySignaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometryThe catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexesExpression of phosphoinositide-specific phospholipase C isoforms in native endothelial cellsFour tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signalingRegulation of neuronal PLCgamma by chronic morphineRegulation of EGF-induced phospholipase C-gamma1 translocation and activation by its SH2 and PH domainsCompetition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.
P2860
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P2860
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
PDGF stimulation of inositol p ...... yrosine residues 783 and 1254.
@en
type
label
PDGF stimulation of inositol p ...... yrosine residues 783 and 1254.
@en
prefLabel
PDGF stimulation of inositol p ...... yrosine residues 783 and 1254.
@en
P2093
P1433
P1476
PDGF stimulation of inositol p ...... yrosine residues 783 and 1254.
@en
P2093
Margolis B
Schlessinger J
Zilberstein A
P304
P356
10.1016/0092-8674(91)90461-7
P407
P577
1991-05-01T00:00:00Z