A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
about
Ubiquitin is phosphorylated by PINK1 to activate parkinPINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentSelf and nonself: how autophagy targets mitochondria and bacteriaProbes of ubiquitin E3 ligases enable systematic dissection of parkin activationThe PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activityKeeping the immune system in check: a role for mitophagy.Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseaseThe ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationPINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control."Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular DisordersHeterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Aberrant autophagy and parkinsonism: does correction rescue from disease progression?Organellophagy: eliminating cellular building blocks via selective autophagy.Defective autophagy in Parkinson's disease: lessons from genetics.How mitochondrial dynamism orchestrates mitophagy.Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and DiseasePhospho-ubiquitin: upending the PINK-Parkin-ubiquitin cascadeAntioxidant modulation in restoring mitochondrial function in neurodegeneration.The mitochondrial kinase PINK1: functions beyond mitophagy.Parkin and mitophagy in cancer.PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.Phosphorylated ubiquitin chain is the genuine Parkin receptor.Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.The crystal structure of pseudokinase PEAK1 (Sugen Kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization.Structure of PINK1 in complex with its substrate ubiquitin.Mammalian mitophagy - from in vitro molecules to in vivo models.Mitochondrial fission facilitates the selective mitophagy of protein aggregates.PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol.Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process.PINK1 autophosphorylation is required for ubiquitin recognition.AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer.
P2860
Q24296532-E763D74F-064E-48E9-AC24-F161E4CC2B80Q24310717-ADA74F6C-F320-442A-9DE6-9F1AE06BFD4BQ26770342-CEA2088F-3491-4EA8-9D1C-7D23502E24D7Q27012602-04E1B9D0-4272-40E3-954F-C6494359805EQ28830194-F51C256F-A372-42D6-A486-15C6F8734EF7Q30846938-D7BF5986-621D-48A3-8F5A-9A2155845279Q34042190-06756AB6-FCD2-4214-BC8A-B7D6ABC79332Q36489290-05C7C001-D107-4F6B-870A-D841185127FCQ36611426-51CB2EE8-EDAE-4501-A8B3-AB866038BA3BQ36636158-47F66208-1632-44AD-B7E4-E43EC1784986Q37603514-2768D9DC-5561-4044-B17E-55BA7A6A9670Q37610585-2ADA7F2B-4727-4FCC-99BC-FBA1E58FE44EQ37736984-A9B671A7-3447-496A-A806-3AE64C4F242DQ38212199-DF15211E-C044-456C-9AAF-12E591E29669Q38215011-61A1F25D-3729-4AD8-9A25-D23268DA9D0DQ38225786-C5D3900A-311F-4430-B629-5BBDBBFFEC46Q38497008-2008DF5A-4E57-481F-AA7D-7C59C4A85FE9Q38641954-81B2F8ED-6B2D-4C8A-AC28-802406D04560Q38721233-E1724F38-DE0D-45A4-BD06-D20EEB261E09Q38807381-82FA8A6E-D3CE-43BD-92E7-488393B7BB31Q38850628-269FC529-A75B-4D5F-9B30-B5D6F806BAF6Q38946190-34218F36-4F40-4B5D-BD42-0B3B83422413Q38971958-1FC43CA1-9375-4B40-96D1-90E0A372D496Q39589823-11D33429-9487-49EC-B21B-5D34748A02FFQ42084360-7AD0142F-6E47-4CBA-B01D-3F3418331CF4Q42275369-5139BF5B-6624-4653-A527-5FDC0F8485C9Q43165330-B1C1ADF5-600F-4549-AAEF-6C95D9A257B6Q43273832-3C65BDFA-CFF1-46C6-9664-0215CE9AE757Q45982558-616E46E8-83BD-47EF-BDA6-954F7EB279DFQ47147993-7C70DB8A-DA33-4838-8536-C05D67490671Q47322504-0B5D3EF3-8FF5-4E35-BC5D-E6EAA58FC54EQ47379543-08241442-3C8B-42FD-8832-47DBFB04E73CQ47389227-461D552F-AAE7-407E-BE01-C97CB5F55916Q47820990-E3B0C08D-75CD-4618-A457-37EE495AEA4FQ49371050-C35AA08C-76BC-4E9F-B483-621A78FB0693Q52559939-09E28F7D-EA6B-4A3B-89CA-71D215F4BF89Q52687770-4B329DAE-8026-4C43-873E-37F480824308Q55360857-D67A6F07-859E-4F72-92EF-F70F4605ED07Q55437754-1E6AD3C2-CDB9-4B08-B0F4-79BCE88BDDDB
P2860
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
A dimeric PINK1-containing com ...... stimulates Parkin recruitment.
@en
type
label
A dimeric PINK1-containing com ...... stimulates Parkin recruitment.
@en
prefLabel
A dimeric PINK1-containing com ...... stimulates Parkin recruitment.
@en
P2093
P2860
P356
P1476
A dimeric PINK1-containing com ...... stimulates Parkin recruitment
@en
P2093
Fumika Koyano
Kei Okatsu
Keiji Tanaka
Mayumi Kimura
Midori Uno
Toshihiko Oka
P2860
P304
36372-36384
P356
10.1074/JBC.M113.509653
P407
P577
2013-11-04T00:00:00Z