Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. - Wikidata - wikimedia - TriplyDB

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

http://www.wikidata.org/entity/Q41982039

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Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells Epithelial cell polarity: a major gatekeeper against cancer?GEMMs as preclinical models for testing pancreatic cancer therapies Molecular landscape of pancreatic cancer: implications for current clinical trials LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis The LKB1-AMPK pathway: metabolism and growth control in tumour suppression LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.Chondroitin sulfate proteoglycan CSPG4 as a novel hypoxia-sensitive marker in pancreatic tumors The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.Longevity, aging and rapamycin.The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.Chemoprevention of pancreatic cancer: ready for the clinic?Familial pancreatic cancer: genetic advances.Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity Integrating physiological regulation with stem cell and tissue homeostasis Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis.Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice.Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism.Genetically engineered mouse models of pancreatic cancer.LKB1 acts as a critical gatekeeper of ovarian primordial follicle pool.LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.

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P2860

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

http://www.wikidata.org/entity/Q41982039

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

@en

type

label

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

@en

prefLabel

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

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Molecular and Cellular Biology

P1476

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

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P2093

Aram F Hezel

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Avital Swisa

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Gerald Bailey

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Gerry C Chu

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Nabeel Bardeesy

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Ronald A Depinho

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Sushma Gurumurthy

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Yuval Dor

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Zvi Granot

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P2860

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

Notch signaling controls multiple steps of pancreatic differentiation

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas

LKB1 tumor suppressor protein: PARtaker in cell polarity

The LKB1 tumor suppressor kinase in human disease

The LKB1 tumor suppressor negatively regulates mTOR signaling

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2414-2425

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10.1128/MCB.01621-07

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7

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28

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Nabeel Bardeesy

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2008-01-28T00:00:00Z

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5625010

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18227155

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2268441

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