In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens.
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Beta class II tubulin predominates in normal and tumor breast tissues.Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growthPrimary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosisIdentification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cellsDifferential distribution of beta-tubulin isotypes in cerebellumClass III β-tubulin counteracts the ability of paclitaxel to inhibit cell migrationAre tubulin isotypes functionally significantDynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dyneinCoordination of posttranslational modifications of bovine brain alpha-tubulin. Polyglycylation of delta2 tubulinA ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferationAssembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunitExpression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunitsMegakaryocyte lineage-specific class VI β-tubulin suppresses microtubule dynamics, fragments microtubules, and blocks cell division.Class V β-tubulin alters dynamic instability and stimulates microtubule detachment from centrosomes.Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway.Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotypeAltered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS.Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongationHypothesis: microtubules, a key to Alzheimer diseaseVinblastine suppresses dynamics of individual microtubules in living interphase cells.Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons.Hypomyelination with atrophy of the basal ganglia and cerebellum: further delineation of the phenotype and genotype-phenotype correlation.Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistanceGene expression profiling of oral squamous cell carcinoma by differential display rt-PCR and identification of tumor biomarkers.Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the 'multi-tubulin' hypothesis.In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different functionGeneration of antisera that discriminate among mammalian alpha-tubulins: introduction of specialized isotypes into cultured cells results in their coassembly without disruption of normal microtubule function.Complex regulation and functional versatility of mammalian alpha- and beta-tubulin isotypes during the differentiation of testis and muscle cells.Differential utilization of beta-tubulin isotypes in differentiating neurites.Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliberCharacterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.Neurofilaments are obligate heteropolymers in vivo.Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells.Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons.Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transportNeurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation.Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.Genetic analysis of a Drosophila microtubule-associated protein.Axonal transport of class II and III beta-tubulin: evidence that the slow component wave represents the movement of only a small fraction of the tubulin in mature motor axons.
P2860
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P2860
In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
In vivo microtubules are copol ...... by synthetic peptide antigens.
@ast
In vivo microtubules are copol ...... by synthetic peptide antigens.
@en
type
label
In vivo microtubules are copol ...... by synthetic peptide antigens.
@ast
In vivo microtubules are copol ...... by synthetic peptide antigens.
@en
prefLabel
In vivo microtubules are copol ...... by synthetic peptide antigens.
@ast
In vivo microtubules are copol ...... by synthetic peptide antigens.
@en
P2860
P356
P1476
In vivo microtubules are copol ...... by synthetic peptide antigens.
@en
P2093
Cleveland DW
P2860
P304
P356
10.1083/JCB.105.4.1707
P407
P577
1987-10-01T00:00:00Z