Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool - Wikidata - wikimedia - TriplyDB

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

http://www.wikidata.org/entity/Q42009559

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Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?NAD+ as a signaling molecule modulating metabolism Redox control of glutamine utilization in cancer NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells.Increasing NAD synthesis in muscle via nicotinamide phosphoribosyltransferase is not sufficient to promote oxidative metabolism.Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains.Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT.NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise.Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells.Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1).Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.The dynamic regulation of NAD metabolism in mitochondria.Maintaining energy homeostasis is an essential component of Wld(S)-mediated axon protection.SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis.Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.NAD and ADP-ribose metabolism in mitochondria.Diversification of NAD biological role: the importance of location.Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury.The human NAD metabolome: Functions, metabolism and compartmentalization.Physiological and pathophysiological roles of NAMPT and NAD metabolism.Protein acetylation in metabolism - metabolites and cofactors.Pyridine Dinucleotides from Molecules to Man.

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P2860

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

http://www.wikidata.org/entity/Q42009559

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Inhibition of nicotinamide pho ...... chondrial insensitive NAD pool

@en

Inhibition of nicotinamide pho ...... chondrial insensitive NAD pool

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type

label

Inhibition of nicotinamide pho ...... chondrial insensitive NAD pool

@en

Inhibition of nicotinamide pho ...... chondrial insensitive NAD pool

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prefLabel

Inhibition of nicotinamide pho ...... chondrial insensitive NAD pool

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Inhibition of nicotinamide pho ...... chondrial insensitive NAD pool

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JBC.M110.136739

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Journal of Biological Chemistry

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Inhibition of nicotinamide pho ...... chondrial insensitive NAD pool

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Alberto Chiarugi

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Elena Rapizzi

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Flavio Moroni

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Francesca Cialdai

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Giuseppe Faraco

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Gloriano Moneti

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Maria Pittelli

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P2860

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae.

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor

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285

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Laura Formentini

Giovanni Romano

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2010-08-19T00:00:00Z

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20724478

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