High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysCNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialDesign of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsAn educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.Anticancer therapeutic potential of Mn porphyrin/ascorbate systemBioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn siteCytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.Simple biological systems for assessing the activity of superoxide dismutase mimics.Protein damage by photo-activated Zn(II) N-alkylpyridylporphyrins.Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Therapeutic potential of peroxynitrite decomposition catalysts: a patent review.Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles.Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity.Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide.Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: potentiometric, spectrophotometric and spectroelectrochemical study of protolytic and redox equilibria.Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria.Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins.Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+).Important cellular targets for antimicrobial photodynamic therapy.Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.Effects of pluronic silica nanoparticles on the photophysical and photodynamic therapy behavior of triphenyl-p-phenoxy benzoic acid metalloporphyrinsPorphyrin-crosslinked block copolymer assemblies as photophysically-active nanoscopic devices
P2860
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P2860
High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
High lipophilicity of meta Mn
@nl
High lipophilicity of meta Mn( ...... ase-deficient Escherichia coli
@en
type
label
High lipophilicity of meta Mn
@nl
High lipophilicity of meta Mn( ...... ase-deficient Escherichia coli
@en
prefLabel
High lipophilicity of meta Mn
@nl
High lipophilicity of meta Mn( ...... ase-deficient Escherichia coli
@en
P2093
P2860
P356
P1476
High lipophilicity of meta Mn( ...... ase-deficient Escherichia coli
@en
P2093
Ines Batinić-Haberle
Ivan Spasojević
P2860
P304
P356
10.1021/JM900576G
P407
P577
2009-12-01T00:00:00Z