Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
about
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionSystematic identification of regulatory proteins critical for T-cell activationSHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activationTyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckCalcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathwayTyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signalingItk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitmentVav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathwaysLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysRegulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinasesDifferential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesCharacterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cellsFyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cellsThe lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNKImaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment.Zap70 inhibits Syk-mediated osteoclast function.Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Zap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation.Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanismZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulationLck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell developmentPartially phosphorylated T cell receptor zeta molecules can inhibit T cell activation.Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia.Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinaseMonovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.Adhesion to fibronectin promotes the activation of the p125(FAK)/Zap-70complex in human T cells.Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking.Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration.Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signalingTyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.
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P2860
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
@en
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
@nl
type
label
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
@en
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
@nl
prefLabel
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
@en
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
@nl
P2093
P2860
P356
P1476
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
@en
P2093
P2860
P304
P356
10.1084/JEM.183.2.611
P407
P577
1996-02-01T00:00:00Z