Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins.
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An aminopeptidase, ARTS-1, is required for interleukin-6 receptor sheddingCellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cellsADAM17 deficiency by mature neutrophils has differential effects on L-selectin sheddingAlcohol reversibly disrupts TNF-alpha/TACE interactions in the cell membraneGrowth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysisRoles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain sheddingActive-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo.RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serumBlockade of IL-6 Trans signaling attenuates pulmonary fibrosisTransmodulation of cell surface regulatory molecules via ectodomain shedding.Reduction of Serum ADAM17 Level Accompanied with Decreased Cytokines after Abatacept Therapy in Patients with Rheumatoid ArthritisMesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferationThe role of soluble common gamma chain in autoimmune disease.Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification.Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer.Proteasomes mediate prolactin-induced receptor down-regulation and fragment generation in breast cancer cellsInterleukin-6 trans-signalling in chronic inflammation and cancer.Leukocyte cell surface proteinases: regulation of expression, functions, and mechanisms of surface localization.sIL-6R: more than an agonist?Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells.Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.Interleukin-6: a new therapeutic target in systemic sclerosis?The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease.Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.Dopamine Increases CD14+CD16+ Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis.Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch.Ectodomain shedding of the glycoprotein GP of Ebola virus.Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE).Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme.A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling.Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin.
P2860
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P2860
Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Shedding of interleukin-6 rece ...... ern of transmembrane proteins.
@en
Shedding of interleukin-6 rece ...... ern of transmembrane proteins.
@nl
type
label
Shedding of interleukin-6 rece ...... ern of transmembrane proteins.
@en
Shedding of interleukin-6 rece ...... ern of transmembrane proteins.
@nl
prefLabel
Shedding of interleukin-6 rece ...... ern of transmembrane proteins.
@en
Shedding of interleukin-6 rece ...... ern of transmembrane proteins.
@nl
P2093
P2860
P1433
P1476
Shedding of interleukin-6 rece ...... ern of transmembrane proteins.
@en
P2093
P2860
P304
P356
10.1046/J.1432-1327.2000.01278.X
P407
P577
2000-05-01T00:00:00Z