Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein.
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Evolution of the hyaluronan-binding module of link proteinFibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domainStructure of the human aggrecan gene: exon-intron organization and association with the protein domainsNeutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecanMatrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domainThe expression of functional link protein in a baculovirus system: analysis of mutants lacking the A, B and B' domainsInteraction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturationIdentification of hyaluronan-binding domains of aggrecanCartilage proteoglycans: structure and potential functions.Structure and function of aggrecan.The different roles of aggrecan interaction domainsThe protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily.Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilageBEHAB, a new member of the proteoglycan tandem repeat family of hyaluronan-binding proteins that is restricted to the brain.The role of aggrecan in normal and osteoarthritic cartilage.Biomimetic molecules lower catabolic expression and prevent chondroitin sulfate degradation in an osteoarthritic ex vivo modelIdentification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.Identity of urinary trypsin inhibitor-binding protein to link protein.Molecular cloning and analysis of the protein modules of aggrecans.Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism.Versican gene expression in human articular cartilage and comparison of mRNA splicing variation with aggrecan.Type VI collagen microfibrils: evidence for a structural association with hyaluronan.Evidence of a defined spatial arrangement of hyaluronate in the central filament of cartilage proteoglycan aggregates.Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.Molecular cloning of chicken aggrecan. Structural analyses.Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.Proteoglycans of human articular cartilage. Identification of several populations of large and small proteoglycans and of hyaluronic acid-binding proteins in successive cartilage extracts.1-C-6 epitope in cartilage proteoglycan G2 domain is masked by keratan sulphate.The major proteoglycan of adult rabbit skeletal muscle. Relationship to small proteoglycans of other tissues.Metalloproteinase digestion of cartilage proteoglycan. Pattern of cleavage by stromelysin and susceptibility to collagenase.The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing iMapping the hyaluronan-binding site on the link module from human tumor necrosis factor-stimulated gene-6 by site-directed mutagenesis.Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins.Lumbar disk degeneration disease and aggrecan gene polymorphism in northern Iran.Interferon-beta inhibits the expression of metalloproteinases in rat glial cell cultures: implications for multiple sclerosis pathogenesis and treatment.Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate.Fell-Muir lecture: cartilage 2010 - the known unknowns.Biomimetic aggrecan reduces cartilage extracellular matrix from degradation and lowers catabolic activity in ex vivo and in vivo models.
P2860
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P2860
Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Isolation of the N-terminal gl ...... hyaluronate and link protein.
@en
Isolation of the N-terminal gl ...... hyaluronate and link protein.
@nl
type
label
Isolation of the N-terminal gl ...... hyaluronate and link protein.
@en
Isolation of the N-terminal gl ...... hyaluronate and link protein.
@nl
prefLabel
Isolation of the N-terminal gl ...... hyaluronate and link protein.
@en
Isolation of the N-terminal gl ...... hyaluronate and link protein.
@nl
P2860
P356
P1433
P1476
Isolation of the N-terminal gl ...... hyaluronate and link protein.
@en
P2093
P2860
P304
P356
10.1042/BJ2610801
P407
P577
1989-08-01T00:00:00Z