Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.
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T cell receptor signalling in the control of regulatory T cell differentiation and functionDisturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus ErythematosusCellular and molecular determinants for the development of natural and induced regulatory T cellsThymus, innate immunity and autoimmune arthritis: interplay of gene and environmentThe thymus and rheumatology: should we care?A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG miceType I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection.Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis.Detection of T cell responses to a ubiquitous cellular protein in autoimmune diseaseExpansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes.SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers gameZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice.T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells.TCR affinity and specificity requirements for human regulatory T-cell functionPak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral TolerancePTPN22 alters the development of regulatory T cells in the thymus.Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell FunctionThe janus head of T cell aging - autoimmunity and immunodeficiency.SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complexLoss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.T cell Receptor Signal Transduction in T lymphocytes.Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood.Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.The degree of CD4+ T cell autoreactivity determines cellular pathways underlying inflammatory arthritisHigh Chlamydia Burden Promotes Tumor Necrosis Factor-Dependent Reactive Arthritis in SKG Mice.Effector T cells in rheumatoid arthritis: lessons from animal models.TCR diversity and Treg cells, sometimes more is more.T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man.Forkhead box P3: the peacekeeper of the immune system.Signals and pathways controlling regulatory T cells.Identification, Isolation, and Functional Assay of Regulatory T Cells.A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling.The SKG Mutation in ZAP-70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains.
P2860
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P2860
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Graded attenuation of TCR sign ...... nd regulatory T cell function.
@en
Graded attenuation of TCR sign ...... nd regulatory T cell function.
@nl
type
label
Graded attenuation of TCR sign ...... nd regulatory T cell function.
@en
Graded attenuation of TCR sign ...... nd regulatory T cell function.
@nl
prefLabel
Graded attenuation of TCR sign ...... nd regulatory T cell function.
@en
Graded attenuation of TCR sign ...... nd regulatory T cell function.
@nl
P2093
P50
P356
P1476
Graded attenuation of TCR sign ...... and regulatory T cell function
@en
P2093
Akira Shimizu
Chihiro Fujimori
Hiroyuki Yoshitomi
Motomu Hashimoto
Noriko Sakaguchi
Satoshi Tanaka
Shimon Sakaguchi
Shin Teradaira
Shinji Maeda
Takashi Nomura
P304
P356
10.4049/JIMMUNOL.1000848
P407
P577
2010-07-19T00:00:00Z