Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.
about
Metabolic actions of Rho-kinase in periphery and brainRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytescGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytesRenal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures.Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.Adiponectin resistance and vascular dysfunction in the hyperlipidemic statePersistent organic pollutant exposure leads to insulin resistance syndromeMolecular mechanism of insulin resistance in obesity and type 2 diabetes.Rho kinase: an important mediator of atherosclerosis and vascular disease.Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine.Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes.A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cellsRho kinase as a therapeutic target in cardiovascular disease.Molecular mechanism of size control in development and human diseases.Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerizationLipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway.Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells.Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndromeThe Rho kinases I and II regulate different aspects of myosin II activity.Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesisRegulating insulin signaling and beta-cell function through IRS proteins.Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.Rho kinase in the regulation of cell death and survival.Tumor necrosis factor-alpha antagonism improves vasodilation during hyperinsulinemia in metabolic syndrome.Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.Applying a targeted label-free approach using LC-MS AMT tags to evaluate changes in protein phosphorylation following phosphatase inhibition.Increased Rho kinase activity in a Taiwanese population with metabolic syndrome.A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylationRho kinase inhibition improves endothelial function in human subjects with coronary artery disease.Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.
P2860
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P2860
Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Active Rho kinase (ROK-alpha ) ...... vascular smooth muscle cells.
@en
Active Rho kinase
@nl
type
label
Active Rho kinase (ROK-alpha ) ...... vascular smooth muscle cells.
@en
Active Rho kinase
@nl
prefLabel
Active Rho kinase (ROK-alpha ) ...... vascular smooth muscle cells.
@en
Active Rho kinase
@nl
P2093
P2860
P356
P1476
Active Rho kinase (ROK-alpha ) ...... n vascular smooth muscle cells
@en
P2093
Masaaki Ito
Najma Begum
Oana A Sandu
Suzanne M Lohmann
P2860
P304
P356
10.1074/JBC.M110508200
P407
P577
2001-12-05T00:00:00Z