Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
about
Small molecules that enhance the catalytic efficiency of HLA-DMHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesThe Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IISusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionHLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideAn unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DMThe melting pot of the MHC II peptidomeCell surface display of functional human MHC class II proteins: yeast display versus insect cell displayEvaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stabilityThe relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes.HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-livesHLA-DR: molecular insights and vaccine design.Recent advances in antigen processing and presentation.Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilingsStructural Insights Into HLA-DM Mediated MHC II Peptide Exchange.Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection.Type 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptidesPeptidomic analysis of type 1 diabetes associated HLA-DQ molecules and the impact of HLA-DM on peptide repertoire editing.DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations.Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design.High-level intrinsic disorder explains the universality of CLIP binding to diverse MHC class II variants.
P2860
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P2860
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
@en
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
@nl
type
label
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
@en
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
@nl
prefLabel
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
@en
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
@nl
P2093
P1476
Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
@en
P2093
Elizabeth D Mellins
Harden M McConnell
Kai W Wucherpfennig
Michael P Belmares
Robert Busch
P304
P356
10.4049/JIMMUNOL.169.9.5109
P407
P577
2002-11-01T00:00:00Z