Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
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Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesCarcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolismExpression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intoleranceOverexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors.Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathwayThe role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus.Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.Expression of DGAT2 in white adipose tissue is regulated by central leptin action.Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling.PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.
P2860
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P2860
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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2003年學術文章
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name
Pdx1 expression in Irs2-defici ...... in a strain-dependent manner.
@en
Pdx1 expression in Irs2-defici ...... in a strain-dependent manner.
@nl
type
label
Pdx1 expression in Irs2-defici ...... in a strain-dependent manner.
@en
Pdx1 expression in Irs2-defici ...... in a strain-dependent manner.
@nl
prefLabel
Pdx1 expression in Irs2-defici ...... in a strain-dependent manner.
@en
Pdx1 expression in Irs2-defici ...... in a strain-dependent manner.
@nl
P2093
P2860
P356
P1476
Pdx1 expression in Irs2-defici ...... d in a strain-dependent manner
@en
P2093
Christopher V E Wright
Hideaki Kaneto
Kajuro Komeda
Kazuhiro Eto
Kazuyuki Tobe
Kousuke Azuma
Michael S German
Naoto Kubota
Ryo Suzuki
Ryozo Nagai
P2860
P304
43691-43698
P356
10.1074/JBC.M307004200
P407
P577
2003-07-16T00:00:00Z