Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
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Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaIdentification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survivalDysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesDiabetes outfoxed by GLP-1?Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own HandsSpecific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survivalInsulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liverGenetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistanceCurrent views on type 2 diabetes.Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growthDeficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model.Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in miceBetacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors.Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice.The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes.Repurposing cAMP-modulating medications to promote β-cell replication.Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cellsInhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Knockouts of SOD1 and GPX1 exert different impacts on murine islet function and pancreatic integrityRIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.Ins1(Cre) knock-in mice for beta cell-specific gene recombination.Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity.Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activationMechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids.Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington diseaseFoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytesSpecific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells.mTORC1 signaling and regulation of pancreatic β-cell mass.IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behaviorAPPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in miceMicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosisOn the role of IRS2 in the regulation of functional beta-cell mass.Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.Chronic activation of a designer G(q)-coupled receptor improves β cell function.Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.
P2860
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P2860
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
@en
type
label
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
@en
prefLabel
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
@en
P2093
P2860
P356
P1476
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
@en
P2093
Anita M Hennige
Deborah J Burks
Mark Zakaria
Markus Schubert
Matt A Dow
Rebecca Leshan
Rohit N Kulkarni
Sunmin Park
Tracey L Fisher
P2860
P304
P356
10.1172/JCI18581
P407
P577
2003-11-01T00:00:00Z