Dimerization of MLL fusion proteins immortalizes hematopoietic cells. - Wikidata - wikimedia - TriplyDB

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

http://www.wikidata.org/entity/Q44615522

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3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) gene Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression New insight into the molecular mechanisms of MLL-associated leukemia Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization Disordered epigenetic regulation in MLL-related leukemia.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.MLL associates specifically with a subset of transcriptionally active target genes.Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis.PAFc, a key player in MLL-rearranged leukemogenesis.Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.The MLL recombinome of acute leukemias in 2013.Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression.Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin.PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.Linking the epigenetic 'language' of covalent histone modifications to cancer.MLL fusions: pathways to leukemia The pathogenesis of mixed-lineage leukemia.CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.The MLL partial tandem duplication in acute myeloid leukaemia.A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.TET1 plays an essential oncogenic role in MLL-rearranged leukemia Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes.Therapeutic targeting of MLL.Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia The molecular biology of mixed lineage leukemia.Molecular pathology of mixed-lineage leukemia.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia.Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway.The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.Mixed lineage leukemia protein in normal and leukemic stem cells.

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P2860

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

http://www.wikidata.org/entity/Q44615522

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

@en

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

@nl

type

label

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

@en

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

@nl

prefLabel

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

@en

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

@nl

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Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

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Denise Gibbs

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Hugh W Brock

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Jay L Hess

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Karine Galoian

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Mary Ellen Martin

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Robert Slany

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Sebastien Bloyer

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Weiping Shen

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197-207

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scholarly article

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10.1016/S1535-6108(03)00214-9

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