Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
about
The NEDD8 modification pathway in plantsTRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancersRibosomal proteins are targets for the NEDD8 pathwayE2-RING expansion of the NEDD8 cascade confers specificity to cullin modificationNEDD8 acts as a 'molecular switch' defining the functional selectivity of VHLInhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapyE2-binding surface on Uba3 β-grasp domain undergoes a conformational transitionp73 as a pharmaceutical target for cancer therapyEukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivityTP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Protein neddylation: beyond cullin-RING ligases.Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.p53 Family and Cellular Stress Responses in Cancer.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapyNedd8 regulates inflammasome-dependent caspase-1 activation.Neddylation and deneddylation in cardiac biologyRegulation of p73 activity by post-translational modifications.Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virusNEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins.Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome systemFunction and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review seriesRegulatory feedback loop between TP73 and TRIM32.Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.Insights from mouse models into human retinoblastomap53-family proteins and their regulators: hubs and spokes in tumor suppression.Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer.CRL Ubiquitin Ligases and DNA Damage Response.Mdm2 and MdmX as Regulators of Gene ExpressionThe TP73 complex network: ready for clinical translation in cancer?A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression.Effects of the NEDD8-activating enzyme inhibitor MLN4924 on lytic reactivation of Kaposi's sarcoma-associated herpesvirusNEDDylation controls the target specificity of E2F1 and apoptosis induction.NEDDylation regulates E2F-1-dependent transcriptionNUB1, an interferon-inducible protein, mediates anti-proliferative actions and apoptosis in renal cell carcinoma cells through cell-cycle regulation.Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells.Chemotherapy induces NEDP1-mediated destabilization of MDM2.TIP60 represses transcriptional activity of p73beta via an MDM2-bridged ternary complex.Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes.A linker strategy for trans-FRET assay to determine activation intermediate of NEDDylation cascade.
P2860
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P2860
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
@en
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
@nl
type
label
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
@en
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
@nl
prefLabel
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
@en
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
@nl
P2093
P2860
P356
P1476
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.
@en
P2093
Alvaro Blanch
Dan C C Lin
Ian R Watson
Meredith S Irwin
Michael Ohh
P2860
P304
34096-34103
P356
10.1074/JBC.M603654200
P407
P577
2006-09-14T00:00:00Z