Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
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Molecular basis of calcium-sensitizing and desensitizing mutations of the human cardiac troponin C regulatory domain: a multi-scale simulation studyRationally engineered Troponin C modulates in vivo cardiac function and performance in health and diseaseCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeMyofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and RelaxationEffects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin CStructure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugsThin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems.Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates.Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performanceCalcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscleThe positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity.Engineering Parvalbumin for the Heart: Optimizing the Mg Binding Properties of Rat β-ParvalbuminMultiscale Estimation of Binding Kinetics Using Brownian Dynamics, Molecular Dynamics and Milestoning.Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational studyKinetic mechanism of the Ca2+-dependent switch-on and switch-off of cardiac troponin in myofibrils.In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility GeneThe rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation.Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin CA Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.Functional and evolutionary relationships of troponin C.Slowed Dynamics of Thin Filament Regulatory Units Reduces Ca(2+)-Sensitivity of Cardiac Biomechanical Function.Divergent Soybean Calmodulins Respond Similarly to Calcium Transients: Insight into Differential Target Regulation.Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies.Visualizing the principal component of ¹H, ¹⁵N-HSQC NMR spectral changes that reflect protein structural or functional properties: application to troponin C.Designing proteins to combat disease: Cardiac troponin C as an example.Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations.Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.Molecular and functional consequences of mutations in the central helix of cardiac troponin C.The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29QMolecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study.Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C.Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties.Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.A quantitative analysis of cardiac myocyte relaxation: a simulation study.Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.
P2860
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P2860
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
@en
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
@nl
type
label
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
@en
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
@nl
prefLabel
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
@en
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
@nl
P2860
P356
P1476
Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.
@en
P2093
Jonathan P Davis
Svetlana B Tikunova
P2860
P304
35341-35352
P356
10.1074/JBC.M405413200
P407
P577
2004-06-16T00:00:00Z