Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance.
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Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet.Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnetCurrent perspectives on HIV-1 antiretroviral drug resistancePyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B PolymeraseStructural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceHIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT InhibitorsStructural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse TranscriptaseInteractions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-templateClicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanismsHIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action.Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.Structures of reverse transcriptase pre- and post-excision complexes shed new light on HIV-1 AZT resistanceRNA transcript 3'-proximal sequence affects translocation bias of RNA polymerase.Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovirInhibition of HIV-1 reverse transcription: basic principles of drug action and resistance.Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tractEffect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant.NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybridsMechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation.The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition.Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNHIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.
P2860
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P2860
Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Site-specific footprinting rev ...... slocation and drug resistance.
@en
Site-specific footprinting rev ...... slocation and drug resistance.
@nl
type
label
Site-specific footprinting rev ...... slocation and drug resistance.
@en
Site-specific footprinting rev ...... slocation and drug resistance.
@nl
prefLabel
Site-specific footprinting rev ...... slocation and drug resistance.
@en
Site-specific footprinting rev ...... slocation and drug resistance.
@nl
P2860
P356
P1476
Site-specific footprinting rev ...... slocation and drug resistance.
@en
P2093
Bruno Marchand
Matthias Götte
P2860
P304
35362-35372
P356
10.1074/JBC.M304262200
P407
P577
2003-06-20T00:00:00Z