Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
about
Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication fociSomatic hypermutation of the AID transgene in B and non-B cellsDysregulated TCL1 promotes multiple classes of mature B cell lymphoma.Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomasMicroRNA-155 is a negative regulator of activation-induced cytidine deaminaseMutations, kataegis and translocations in B cells: understanding AID promiscuous activityThe genetic landscape of diffuse large B-cell lymphomaRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationAID targeting is dependent on RNA polymerase II pausing.AID/APOBEC deaminases and cancerRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeHypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomasNon-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implicationsConvergent transcription at intragenic super-enhancers targets AID-initiated genomic instabilityThe response to and repair of RAG-mediated DNA double-strand breaksAID targeting: old mysteries and new challengesAID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingAID and Apobec3G haphazard deamination and mutational diversityA cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.Role of the translocation partner in protection against AID-dependent chromosomal translocationsLymphoma stem cells: enough evidence to support their existence?Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Attracting AID to targets of somatic hypermutation.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Genome system architecture and natural genetic engineering in evolution.Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytesSomatic hypermutation of immunoglobulin and non-immunoglobulin genes.The reverse transcriptase model of somatic hypermutationRegulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6.Origin of chromosomal translocations in lymphoid cancer.Genome-wide somatic hypermutation.BCL-6 in the pathogenesis of non-Hodgkin's lymphoma.Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cellsA target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionInternal deletions within the BCL6 gene in B-cell non-Hodgkin's lymphoma.Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNAThe B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.Somatic immunoglobulin hypermutation.
P2860
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P2860
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Mutation of BCL-6 gene in norm ...... tic hypermutation of Ig genes.
@en
Mutation of BCL-6 gene in norm ...... tic hypermutation of Ig genes.
@nl
type
label
Mutation of BCL-6 gene in norm ...... tic hypermutation of Ig genes.
@en
Mutation of BCL-6 gene in norm ...... tic hypermutation of Ig genes.
@nl
prefLabel
Mutation of BCL-6 gene in norm ...... tic hypermutation of Ig genes.
@en
Mutation of BCL-6 gene in norm ...... tic hypermutation of Ig genes.
@nl
P2093
P1433
P1476
Mutation of BCL-6 gene in norm ...... tic hypermutation of Ig genes.
@en
P2093
P304
P356
10.1126/SCIENCE.280.5370.1750
P407
P577
1998-06-01T00:00:00Z