Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.
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Plant Lessons: Exploring ABCB Functionality Through Structural ModelingProjection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.The ABC protein turned chloride channel whose failure causes cystic fibrosisProviding a molecular mechanism for P-glycoprotein; why would I bother?Different modalities of intercellular membrane exchanges mediate cell-to-cell p-glycoprotein transfers in MCF-7 breast cancer cells.Molecular models of human P-glycoprotein in two different catalytic statesExon 10 CFTR gene mutation in male infertilityThe structures of MsbA: Insight into ABC transporter-mediated multidrug efflux.Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.ABC multidrug transporters: structure, function and role in chemoresistance.Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscsConformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2.Distinct N-glycan glycosylation of P-glycoprotein isolated from the human uterine sarcoma cell line MES-SA/Dx5Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.New horizon of MDR1 (P-glycoprotein) study.The translocation mechanism of P-glycoprotein.Insight in eukaryotic ABC transporter function by mutation analysis.Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Computer simulations of ABC transporter components.Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.Modeling kinetics of subcellular disposition of chemicals.Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbAComplex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function.Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.The P-glycoprotein multidrug transporter.Structure of a human multidrug transporter in an inward-facing conformation.Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport.Attempts to characterize the NBD heterodimer of MRP1: transient complex formation involves Gly771 of the ABC signature sequence but does not enhance the intrinsic ATPase activity.New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors.Homology modeling and binding site assessment of the human P-glycoprotein.The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone.Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.The Q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug ABC transporter BmrA.Molecular dynamics simulations of E. coli MsbA transmembrane domain: formation of a semipore structureNucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.Exploring the minimal functional unit of the transporter associated with antigen processing.Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates.Development of a UPLC-TQ/MS Approach for the Determination of Eleven Bioactive Components in Haizao Yuhu Decoction Plus-Minus Haizao and Gancao Drug Combination after Oral Administration in a Rat Model of Hypothyroidism.Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).
P2860
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P2860
Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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name
Three-dimensional structure of ...... in the nucleotide-bound state.
@en
Three-dimensional structure of ...... in the nucleotide-bound state.
@nl
type
label
Three-dimensional structure of ...... in the nucleotide-bound state.
@en
Three-dimensional structure of ...... in the nucleotide-bound state.
@nl
prefLabel
Three-dimensional structure of ...... in the nucleotide-bound state.
@en
Three-dimensional structure of ...... in the nucleotide-bound state.
@nl
P2093
P2860
P356
P1476
Three-dimensional structure of ...... in the nucleotide-bound state.
@en
P2093
Christopher F Higgins
Mark F Rosenberg
Szabolcs Modok
P2860
P304
P356
10.1074/JBC.M410296200
P407
P577
2004-10-13T00:00:00Z