A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.
about
P1343
The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signalingPurified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinityThe ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase BBRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sitesGlucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cellsInsulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivationInvolvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cellsRaf-1 is a potential substrate for mitogen-activated protein kinase in vivo.Insulin stimulates the biosynthesis of chiro-inositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor.Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growthIntermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae.Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin.In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studiesMonoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements.Specific factors are required for kinase-dependent endocytosis of insulin receptors.Functionally distinct insulin receptors generated by tissue-specific alternative splicing.Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transductionEndocytotic uptake, processing, and retroendocytosis of human biosynthetic proinsulin by rat fibroblasts transfected with the human insulin receptor gene.Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotypeTwo steps of insulin receptor internalization depend on different domains of the beta-subunit.Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane regionThe insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascadeInsulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expressionThe mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNA-dependent, interferon-induced protein kinase, PKR.Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytesReconstitution of an insulin signaling pathway in Xenopus laevis oocytes: coexpression of a mammalian insulin receptor and three different mammalian hexose transportersHuman transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domainInsulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.Insulin and insulinlike growth factor 1 (IGF-1) receptors during central nervous system development: expression of two immunologically distinct IGF-1 receptor beta subunits.Disruption of the CD4-p56lck complex is required for rapid internalization of CD4.Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors.Proximity measurements between H-2 antigens and the insulin receptor by fluorescence energy transfer: evidence that a close association does not influence insulin binding.
P2860
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P2860
A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
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1987年学术文章
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1987年学术文章
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1987年学术文章
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1987年学术文章
@zh-my
1987年学术文章
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1987年學術文章
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1987年學術文章
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name
A mutant insulin receptor with ...... does not undergo endocytosis.
@en
A mutant insulin receptor with ...... does not undergo endocytosis.
@nl
type
label
A mutant insulin receptor with ...... does not undergo endocytosis.
@en
A mutant insulin receptor with ...... does not undergo endocytosis.
@nl
prefLabel
A mutant insulin receptor with ...... does not undergo endocytosis.
@en
A mutant insulin receptor with ...... does not undergo endocytosis.
@nl
P2093
P1476
A mutant insulin receptor with ...... does not undergo endocytosis.
@en
P2093
P304
14663-14671
P407
P4510
P577
1987-10-01T00:00:00Z